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Related Experiment Video

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Controlled Synthesis and Fluorescence Tracking of Highly Uniform PolyN-isopropylacrylamide Microgels
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Surface-bound microgels - From physicochemical properties to biomedical applications.

Lina Nyström1, Martin Malmsten2

  • 1Department of Pharmacy, Uppsala University, P.O. Box 580, SE 751 23 Uppsala, Sweden.

Advances in Colloid and Interface Science
|November 21, 2016
PubMed
Summary

Surface-bound microgels provide versatile methods for modifying surfaces and introducing biological functions. These microgel systems offer facile and robust approaches for applications in drug delivery and biomaterials.

Keywords:
BiomaterialBiosensorDrug deliveryMicrogelSurface-bound

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Area of Science:

  • Materials Science
  • Biotechnology

Background:

  • Microgels offer robust and facile surface modification.
  • They enable the introduction of biological functionality through bioactive agent loading.
  • Microgels provide a versatile alternative to complex bottom-up surface design methods.

Approach:

  • Discusses properties of surface-bound microgels.
  • Covers physical adsorption, covalent grafting, and directed self-assembly.
  • Explores multilayer structures, composites, and cargo loading/release.

Key Points:

  • Surface-bound microgels facilitate the design of surfaces with predetermined characteristics.
  • Applications include drug delivery, functional biomaterials, and biosensors.
  • Various methods for immobilizing and structuring microgels are presented.

Conclusions:

  • Surface-bound microgels are a versatile platform for advanced material design.
  • Their properties and applications span from fundamental surface science to biomedical engineering.
  • This review highlights the potential of microgels in creating functional surfaces.