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Related Experiment Video

Updated: Mar 11, 2026

A Novel Stromal Fibroblast-Modulated 3D Tumor Spheroid Model for Studying Tumor-Stroma Interaction and Drug Discovery

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The Interaction Between Human Papillomaviruses and the Stromal Microenvironment.

B Woodby¹, M Scott¹, J Bodily¹

¹Louisiana State University Health Sciences Center, Shreveport, LA, United States.

Progress in Molecular Biology and Translational Science

|November 21, 2016

Summary

Human papillomaviruses (HPVs) impact tissue by interacting with the stromal microenvironment. This review explores how these interactions influence HPV infection and cancer progression.

Keywords:

Angiogenesis Cell-mediated immunity Epithelial–stromal interaction Fibroblast Growth factors Innate immunity Interferon Microenvironment Papillomavirus

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Published on: July 23, 2010

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Last Updated: Mar 11, 2026

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In situ Subcellular Fractionation of Adherent and Non-adherent Mammalian Cells

In situ Subcellular Fractionation of Adherent and Non-adherent Mammalian Cells

Published on: July 23, 2010

Area of Science:

Virology
Cancer Biology
Cell Biology

Background:

Human papillomaviruses (HPVs) are DNA viruses linked to various cancers.
Understanding HPV persistence and progression requires examining virus-host interactions.
The role of the stromal microenvironment in HPV infection is not well understood.

Purpose of the Study:

To review the impact of keratinocyte-stromal interactions on HPV biology.
To explore how HPV affects stromal cells (fibroblasts, immune cells, endothelial cells).
To discuss reciprocal influences between HPV-infected cells and their environment.

Main Methods:

Literature review of keratinocyte-stromal interactions in HPV biology.
Focus on stromal fibroblasts, immune cells, and endothelial cells.
Analysis of HPV oncogene manipulation of the microenvironment.

Main Results:

HPV oncogenes can manipulate surrounding stromal cells.
Stromal cells may influence HPV infection efficiency and progression.
The bidirectional impact of HPV and stromal interactions is highlighted.

Conclusions:

Stromal microenvironment plays a critical role in HPV life cycle and pathogenesis.
Further research is needed to elucidate these complex interactions for therapeutic strategies.
Understanding these interactions is key to controlling HPV-related diseases.