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Starch functionalized biodegradable semi-IPN as a pH-tunable controlled release platform for memantine
Sayan Ganguly1, Tushar Maity1, Subhadip Mondal1
1Rubber Technology Centre, Indian Institute of Technology, Kharagpur 721302, India.
International Journal of Biological Macromolecules
|November 21, 2016
Summary
This study presents a novel pH-tunable, biodegradable hydrogel synthesized from starch, acrylic acid, and AMPS. The developed semi-interpenetrating polymer network exhibits rapid water absorption and controlled degradation, making it suitable for drug delivery applications.
Area of Science:
- Polymer Chemistry
- Materials Science
- Biomaterials
Background:
- Semi-interpenetrating polymer networks (semi-IPNs) offer unique properties by combining distinct polymer networks.
- Starch-based hydrogels are attractive due to their biodegradability and biocompatibility.
- Developing advanced hydrogels for controlled drug delivery remains a significant challenge.
Purpose of the Study:
- To synthesize and characterize a novel semi-IPN hydrogel based on starch.
- To investigate the pH-tunable swelling behavior and fast water uptake properties.
- To evaluate the biodegradability and potential of the hydrogel as a drug delivery vehicle.
Main Methods:
- Sequential preparation of semi-IPN hydrogel via Michael addition of acrylic acid (AA) and 2-acrylamido-2-methylpropane sulfonic acid (AMPS) onto starch.
- Characterization using Fourier Transformed Infrared Spectroscopy (FTIR) for grafting confirmation.
- Surface morphology analysis via Scanning Electron Microscopy (SEM).
- Thermal stability assessment using Thermogravimetric Analysis (TGA).
- Biodegradation studies using hen egg lysozyme medium.
Main Results:
- FTIR confirmed successful Michael type grafting of AA and AMPS onto starch.
- SEM revealed a corrugated rough surface, enhancing fast water uptake via anomalous Fickian case II diffusion.
- TGA indicated improved thermal stability of the grafted hydrogel.
- Biodegradation studies showed accelerated enzymatic degradation with approximately 60% mass loss within 7 days.
- The hydrogel demonstrated pH-tunable swelling characteristics.
Conclusions:
- The synthesized starch-based semi-IPN hydrogel exhibits excellent water absorption and tunable swelling with pH.
- The hydrogel demonstrates significant biodegradability, making it an environmentally friendly material.
- Its properties suggest strong potential as a pH-tunable, biodegradable candidate for controlled drug delivery systems.
Keywords:
BiodegradationCorrugated rough surfaceDrug deliverySemi interpenetrating polymer networkWater imbibitionpH-tunableMore Related Videos
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