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Related Concept Videos

Disorders of Leukocytes01:27

Disorders of Leukocytes

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Leukocyte disorders can lead to either leukopenia, characterized by an abnormally low leukocyte count, or leukocytosis, marked by a very high leukocyte number.
Leukopenia may result from bone marrow disorders, autoimmune diseases, and infectious diseases. For example, conditions such as multiple myeloma and aplastic anemia can impair the bone marrow's ability to produce adequate leukocytes. Similarly, autoimmune diseases like lupus and viral infections such as HIV can prompt the immune...
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Structure and Function of Leukocytes01:21

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An adult in good health typically has between 4,500 and 11,000 leukocytes, or white blood cells, per microliter of blood, which constitutes about 1% of the total blood volume. Unlike red blood cells, white blood cells contain a nucleus and other cellular organelles but do not have hemoglobin. Most white blood cells reside in connective tissues, particularly in lymphatic organs such as the lymph nodes, with only a small fraction present in circulating blood.
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Classification of Leukocytes01:30

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Leukocytes are classified into two groups based on the presence or absence of cytoplasmic granules. Granular leukocytes, which contain granules, belong to the myeloid lineage and are divided into three subtypes: neutrophils, eosinophils, and basophils. These cells are roughly spherical and characterized by the granules in their cytoplasm.
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Common myeloid progenitors (CMPs) are oligopotent cells that can differentiate into granulocytes and macrophages. Granulocytes and macrophages are essential for protecting the body against bacterial, viral, or fungal infections. They migrate from the bone marrow into the circulating blood to reach specific tissue sites where they differentiate and help in immune surveillance. However, they survive only for a few days and must be continuously made available to the organism to maintain a robust...
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Bone Marrow Sampling and Transplants

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Bone marrow transplant is a potential cure for several diseases, including cancer and specific genetic disorders. Notably, this procedure is applicable for patients suffering from aplastic anemia, certain types of leukemia, severe combined immunodeficiency disease (SCID), Hodgkin's disease, non-Hodgkin's lymphoma, multiple myeloma, thalassemia, sickle-cell disease, and certain cancers.
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Lineage Commitment01:21

Lineage Commitment

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Commitment is the  process whereby stem cells:
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Related Experiment Video

Updated: Mar 11, 2026

Assessment of the Metabolic Profile of Primary Leukemia Cells
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Leukocytosis and Leukemia.

Page Widick1, Eric S Winer2

  • 1Department of Internal Medicine, Rhode Island Hospital, Brown University, JB 0100, 593 Eddy Street, Providence, RI 02903, USA.

Primary Care
|November 22, 2016
PubMed
Summary

Leukocytosis, an elevated white blood cell count, has many causes. This review differentiates between benign conditions like infections and inflammation, and malignant conditions such as leukemia.

Keywords:
InflammationLeukemiaLeukocytosisWhite blood cell count

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Area of Science:

  • Hematology
  • Clinical Pathology

Background:

  • Leukocytosis, a common finding in peripheral blood smears, necessitates differentiation between benign and malignant etiologies.
  • Accurate diagnosis relies on thorough clinical and laboratory assessment.

Purpose of the Study:

  • To explore the diverse causes of leukocytosis.
  • To distinguish between nonmalignant and malignant origins of elevated white blood cell counts.
  • To discuss management strategies for malignant leukocytosis.

Main Methods:

  • Review of infectious, inflammatory, autoimmune, and allergic causes of nonmalignant leukocytosis.
  • Discussion of malignant causes including myeloproliferative disorders and leukemias.
  • Outline of treatment and monitoring protocols for malignant conditions.

Main Results:

  • Nonmalignant leukocytosis encompasses infectious, inflammatory, autoimmune, and allergic processes.
  • Malignant leukocytosis includes myeloproliferative disorders, acute leukemia, and chronic leukemia.
  • Effective management requires tailored treatment and vigilant monitoring.

Conclusions:

  • Differentiating leukocytosis causes is crucial for appropriate patient management.
  • Understanding the spectrum from benign to malignant conditions informs diagnostic and therapeutic decisions.
  • This review provides a comprehensive overview for clinicians managing leukocytosis.