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Related Experiment Video

Updated: Mar 11, 2026

Author Spotlight: Investigating the Pathophysiology of Eosinophilic Esophagitis

Author Spotlight: Investigating the Pathophysiology of Eosinophilic Esophagitis

Published on: May 10, 2024

Eosinophilia.

Anna Kovalszki¹, Peter F Weller²

¹Allergy and Inflammation, Beth Israel Deaconess Medical Center, Harvard Medical School, One Brookline Place Suite 623, Brookline, MA 02445, USA.

|November 22, 2016

Summary

This summary is machine-generated.

Eosinophilia, an increase in blood eosinophils, has diverse causes including infections, allergies, and autoimmune conditions. Understanding these triggers is crucial for primary care physicians to guide appropriate specialist referrals.

Keywords:

Asthma Drug allergy Eosinophilia Eosinophilic gastrointestinal disease Hypereosinophilic syndromes Parasitic disease

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Author Spotlight: Investigating the Pathophysiology of Eosinophilic Esophagitis

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Published on: May 14, 2012

Area of Science:

Hematology
Immunology
Internal Medicine

Background:

Eosinophilia is characterized by elevated blood eosinophil counts, typically between 450-550 cells/μL.
Numerous conditions can lead to eosinophilia, encompassing infectious, allergic, autoimmune, and malignant processes.
Primary eosinophilic disorders, such as hypereosinophilic syndrome, represent a distinct category.

Purpose of the Study:

To outline the broad differential diagnosis of eosinophilia.
To emphasize the importance of recognizing various causes of elevated eosinophils.
To guide primary care physicians on when to refer patients for specialist evaluation.

Main Methods:

Review of existing medical literature on eosinophilia.
Categorization of known causes of eosinophilia.
Clinical guidelines for the management of eosinophilia.

Main Results:

Eosinophilia can stem from parasitic infections, allergic diseases, and connective tissue disorders.
Autoimmune conditions and rheumatologic diseases are significant contributors to eosinophilia.
Malignant states and primary eosinophilic syndromes like HES are also identified causes.

Conclusions:

Primary care physicians require a comprehensive understanding of eosinophilia's diverse etiologies.
Timely recognition of underlying causes is essential for effective patient management.
Appropriate referral to specialty care is critical in managing complex or persistent eosinophilia.