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Author Spotlight: Self-Assessment Protocol for Predicting Psoriatic Arthritis in Psoriasis Patients
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Author Spotlight: Self-Assessment Protocol for Predicting Psoriatic Arthritis in Psoriasis Patients

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Atherosclerosis in Psoriatic Arthritis: A Multiparametric Analysis Using Imaging Technique and Laboratory Markers of

Nidhi Garg1, Pawan Krishan1, Ashit Syngle2

  • 1Department of Pharmaceutical Sciences and Drug Research, Punjabi University, Patiala, Punjab, India.

The International Journal of Angiology : Official Publication of the International College of Angiology, Inc
|November 22, 2016
PubMed

Insights

Psoriatic arthritis (PsA) patients show higher carotid intima-media thickness (CIMT) and impaired vascular function, indicating accelerated atherosclerosis. Inflammation and endothelial dysfunction markers are elevated, contributing to cardiovascular disease risk in PsA.

Area of Science:

  • Rheumatology and Cardiovascular Medicine
  • Immunology and Vascular Biology

Background:

  • Cardiovascular disease is a major cause of mortality in psoriatic arthritis (PsA).
  • The mechanisms driving accelerated atherosclerosis in PsA are not fully understood.
  • Endothelial dysfunction (ED) is an early indicator of atherosclerosis.

Purpose of the Study:

  • To evaluate carotid intima-media thickness (CIMT) as a marker of atherosclerosis in PsA.
  • To assess CIMT in relation to inflammatory markers and vascular function indicators in PsA patients.

Main Methods:

  • A cross-sectional study comparing 18 PsA patients with 18 matched controls.
  • Measurements included carotid intima-media thickness (CIMT), flow-mediated dilatation (FMD), endothelial progenitor cells (EPCs), and various inflammatory markers (ESR, CRP, IL-1, IL-6, TNF-α).
  • Vascular dysfunction markers such as intercellular adhesion molecule 1 (ICAM-1) and vascular cell adhesion molecule 1 (VCAM-1) were also analyzed.

Main Results:

  • PsA patients exhibited significantly higher CIMT compared to controls (p < 0.01).
  • PsA patients showed significantly reduced FMD, EPCs, and high-density lipoproteins (HDL) cholesterol (p < 0.05).
  • Elevated levels of ESR, CRP, TNF-α, IL-6, ICAM-1, and VCAM-1 were observed in PsA patients.

Conclusions:

  • PsA is associated with endothelial dysfunction and accelerated atherosclerosis, evidenced by impaired FMD and increased CIMT.
  • Inflammatory pathways (TNF-α, IL-6) and vascular markers (CRP, ICAM-1, EPCs) are implicated in PsA's vascular disease.
  • Cytokine-driven inflammation may contribute to endothelial dysfunction and increased CIMT in PsA through adhesion molecule upregulation and EPC depletion.

Keywords:
adhesion moleculesatherosclerosiscarotid intima-media thicknessendothelial dysfunctionendothelial progenitor cellsinflammatory cytokinespsoriatic arthritis

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