Related Experiment Video
Updated: Mar 11, 2026

Diagonal Method to Measure Synergy Among Any Number of Drugs
Published on: June 21, 2018
Changes in the Dose-Response Relationship of One Toxicant Under Simultaneous Exposure to Another Toxicant
B A Katsnelson1, V G Panov2, A N Varaksin2
1The Medical Research Center for Prophylaxis and Health Protection in Industrial Workers, Ekaterinburg, Russia.
Abstract:
We considered, in general form for a 22 full factorial experiment, linear approximations of the organism's dose-response relationship for some factors operating alone and modification of this relationship by another factor operating in the background. A typological classification of such modifications is suggested. An analysis of the outcomes obtained in a number of subchronic animal experiments on rats in which this response was assessed by changes in a large number of biomedical indices revealed that all theoretically possible variants (types) of the modification under consideration are actually observed depending on a specific index and specific harmful exposure. Statistical significance estimation procedures are formulated for each of them.
More Related Videos
11:38High Content Screening Analysis to Evaluate the Toxicological Effects of Harmful and Potentially Harmful Constituents HPHC
Published on: May 10, 2016
06:00Experimental Protocol for Using Drosophila As an Invertebrate Model System for Toxicity Testing in the Laboratory
Published on: July 10, 2018
Related Concept Videos
Dose Response Curve: Conventional Versus Nonmonotonic
Drug Toxicity: Dose-Dependent Reactions
Dose-Response Relationship: Overview
Pharmacokinetic–Pharmacodynamic Relationship: Exposure, Response and Effect
Toxic Reactions: Overview
Toxicity falls into two primary categories: local and systemic.
Local toxicity appears at the exposure site, such as protein denaturation caused by caustic substances.
In contrast, systemic toxicity requires the toxic agent's absorption and distribution,...
Drug toxicity: Drug–Drug Interaction