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Related Concept Videos

Treatment for Pulmonary Arterial Hypertension: Oxygen Therapy for Respiratory Failure01:16

Treatment for Pulmonary Arterial Hypertension: Oxygen Therapy for Respiratory Failure

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Oxygen therapy has emerged as a significant tool in enhancing the quality of life for patients suffering from pulmonary arterial hypertension (PAH). While this therapy has principally been studied on patients with significant hypoxemia, this therapeutic approach helps prevent potential organ damage and can be administered in the comfort of one's home.
Oxygen therapy is vital in increasing and maintaining blood oxygen levels in PAH patients. As a result, it aids in reducing fatigue,...
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Hyperbaric oxygen therapy in experimental and clinical stroke.

Wei-Wei Zhai1, Liang Sun1, Zheng-Quan Yu1

  • 1Department of Neurosurgery & Brain and Nerve Research Laboratory, the First Affiliated Hospital of Soochow University, Suzhou, Jiangsu Province, China.

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Summary

Hyperbaric oxygen therapy (HBOT) shows promise for improving neurological outcomes after stroke by enhancing oxygenation and reducing inflammation. However, more rigorous clinical trials are needed to establish optimal HBOT protocols for stroke treatment.

Keywords:
cerebrovascular diseaseclinical studiesexperimental studieshyperbaric oxygen preconditioninghyperbaric oxygen therapyischemiastroke

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Area of Science:

  • Neurology
  • Hyperbaric Medicine
  • Regenerative Medicine

Background:

  • Stroke is a leading cause of death and disability globally, with limited effective treatment options.
  • Current therapies for ischemic stroke have narrow therapeutic windows, excluding many patients.
  • Hyperbaric oxygen therapy (HBOT) has been explored for stroke treatment since the 1960s.

Approach:

  • Review of numerous basic and clinical studies on HBOT for stroke.
  • Investigation of HBOT's neuroprotective mechanisms.
  • Assessment of the evidence base for HBOT in human stroke.

Key Points:

  • HBOT demonstrates potential benefits for neurological outcomes post-stroke.
  • Mechanisms include improved cerebral oxygenation, reduced inflammation, and enhanced neural regeneration.
  • Current evidence is limited by a lack of sufficient randomized controlled trials.

Conclusions:

  • HBOT offers promising neuroprotective effects in stroke.
  • Further research is crucial to clarify mechanisms and establish optimal treatment protocols.
  • Investigating combination therapies with HBOT is an active area of research.