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Updated: Jun 9, 2025
08:17
Generation of a Chronic Obstructive Pulmonary Disease Model in Mice by Repeated Ozone Exposure
Published on: August 25, 2017
10.9K
Ozone: complicated effects in central nervous system diseases
Xu Zhang1, Shi-Jun Wang, Si-Cen Wan
1Department of Neurosurgery, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu Province, China.
Medical Gas Research
|October 22, 2024
Summary
Ozone
Area of Science:
- Biochemistry
- Neuroscience
- Toxicology
Background:
- Oxidative stress is implicated in numerous diseases.
- Ozone's dual nature: potent oxidant causing damage, yet therapeutic at low concentrations.
- Evidence suggests ozone's medical potential beyond its toxicity.
Purpose of the Study:
- To review ozone's mechanisms, therapeutic value in CNS diseases (ischemic stroke, Alzheimer's), and toxic effects.
- To explore ozone's role in oxidative stress response and its potential as a therapeutic agent.
- To assess the impact of antioxidants on ozone's effects.
Main Methods:
- Literature review of animal experiments and clinical studies on ozone therapy.
- Analysis of ozone's redox reactions and signaling pathways.
- Examination of ozone's effects on inflammation and amyloid-beta levels.
Main Results:
- High ozone exposure or lack of antioxidants causes harm.
- Low ozone concentrations with adequate antioxidants can reduce inflammation and amyloid-beta.
- Ozone therapy shows potential for treating ischemic stroke and Alzheimer's disease.
- Ozone improves tissue oxygenation and transmits oxidative stress signals.
Conclusions:
- Ozone exhibits therapeutic potential for central nervous system diseases, particularly ischemic stroke and Alzheimer's disease.
- Adequate antioxidants are crucial for harnessing ozone's beneficial effects and mitigating toxicity.
- Further research is required to establish optimal ozone dosage and efficacy.
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