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Updated: Mar 11, 2026
Preparation and Photoacoustic Analysis of Cellular Vehicles Containing Gold Nanorods
Published on: May 2, 2016
Biodegradable polymeric nanoparticles containing gold nanoparticles and Paclitaxel for cancer imaging and drug
Yanjie Wang1, Eric M Strohm1, Yang Sun2
1Physics Department, Ryerson University, 350 Victoria St., Toronto, Ontario M5B 2K3, Canada; Institute for Biomedical Engineering, Science and Technology (iBEST), a partnership between Ryerson University and St. Michael's Hospital, 30 Bond St., Toronto, Ontario, M5B 1T8, Canada; Keenan Research Centre for Biomedical Science of St. Michael's Hospital, 30 Bond St., Toronto, Ontario, M5B 1T8, Canada.
Abstract:
In this study, optical-triggered multifunctional theranostic agents for photoacoustic/fluorescent imaging and cancer therapy have been developed. This system consists of a perfluorohexane liquid and gold nanoparticles (GNPs) in the core, stabilized by a Poly (lactide-co-glycolic acid) (PLGA) polymer shell. When cancer cells containing PLGA-GNPs were exposed to laser pulses, cell viability decreased due to the vaporization of the particles in and around the cells. The particle chemo drug loading and delivery capacity was also investigated in vitro experiments. These particles show potential as photoacoustic imaging and therapy agents for future clinical translation in cancer therapy.
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