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Quantitative Fundus Autofluorescence for the Evaluation of Retinal Diseases
Published on: March 11, 2016
Time-resolved fluorescence spectroscopy for clinical diagnosis of actinic cheilitis
Alessandro Cosci1, Marcelo Saito Nogueira2, Sebastião Pratavieira3
1Museo Storico della Fisica e Centro Studi e Ricerche Enrico Fermi, Piazza del Viminale 1, 00184 Rome, Italy; IFAC-CNR, Istituto di Fisica Applicata "Nello Carrara," Consiglio Nazionale delle Ricerche, Via Madonna del Piano 10, 50019 Sesto Fiorentino, Italy; São Carlos Institute of Physics, University of São Paulo, PO Box 369, 13560-970, São Carlos, SP Brazil; a.cosci@ifac.cnr.it.
Abstract:
Actinic cheilitis is a potentially malignant disorder of the lips. Its first cause is believed to be UV sun radiation. The lesion is highly heterogeneous, making the choice of area to be biopsied difficult. This study exploits the capabilities of time-resolved fluorescence spectroscopy for the identification of the most representative area to be biopsied. A preliminary study was performed on fourteen patients. A classification algorithm was used on data acquired on nine different biopsies. The algorithm discriminated between absent, mild, and moderate dysplasia with a sensitivity of 92.9%, 90.0%, and 80.0%, respectively. The false positive rate for healthy tissue (specificity) was 88.8%.
