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Evidence for a factor promoting the conversion of VWF from low and intermediate to high molecular mass polymers on
1Istituto di Chimica Biologica, Università degli Studi, Ferrara, Italy.
FEBS Letters
|June 5, 1989
Abstract:
On the membrane surface of resting platelets exists a factor capable of promoting the conversion of plasma von Willebrand factor from low and intermediate molecular mass to high molecular mass polymers. The process is accompanied by a parallel increase in the von Willebrand factor activity. This could be a regulatory system for the molecular mass distribution of von Willebrand factor during its lifetime in plasma. Glycoprotein Ib of the platelet membrane appears not to be involved in the process.