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Updated: Mar 11, 2026

Hyperinsulinemic-euglycemic Clamps in Conscious, Unrestrained Mice
Published on: November 16, 2011
Hypoglycemic Activity of Polysaccharides from Sweet Corncob on Streptozotocin-Induced Diabetic Rats
Yong Qiang Ma1, Xin Wang1, Shuang Gao1
1Key Laboratory Food Science and Engineering, School of Food Engineering, Harbin, Univ. of Commerce, No. 138 Tongda Street, Daoli District, Harbin City, Hei Longjiang, Province China.
Abstract:
A water-soluble polysaccharide (SCP-80-I) was isolated from sweet corncob using microwave-assisted compound-enzyme extraction and column chromatography. SCP-80-I is composed mainly of arabinose, mannose, glucose, and galactose in a molar ratio of 0.369:0.824:10.759:0.333, and has a molecular mass of 18350 Da and β-glycosides linkages in its molecular structure. The preliminary hypoglycemic and hypolipidemic activity in streptozotocin-induced diabetic rats was investigated. Rats were administered daily with 100, 200, and 400 mg/kg SCP-80-I for 21 d. The SCP-80-I increased the rat body mass significantly and reduced the blood glucose level in a dose-dependent manner. The SCP-80-I reduced liver swelling; kidney and pancreas hypertrophy; and total cholesterol, triglyceride, and low-density lipoprotein-C levels significantly; and increased the level of high-density lipoproteins in streptozotocin-induced diabetic rats. These results indicate that SCP-80-I exerts a potential hypoglycemic effect in streptozotocin-induced diabetic rats.
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