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Depression and Liver Transplant Survival
William Meller1, Nicole Welle1, Kristen Sutley1
1Department of Psychiatry, University of Minnesota, Minneapolis, MN.
Psychosomatics
|November 23, 2016
Summary
Liver transplant patients with depression who received treatment showed better survival rates. This suggests treatment adherence may improve outcomes for transplant recipients.
Area of Science:
- Hepatology
- Transplant Surgery
- Psychiatry
Background:
- Liver transplant recipients experiencing depression historically have lower survival rates.
- Depression is a significant comorbidity impacting post-transplant outcomes.
Purpose of the Study:
- To test if medical treatment for depression in liver transplant patients improves survival.
- To determine if seeking treatment for depression mitigates reduced survival rates.
Main Methods:
- Survival analysis of 765 liver transplant patients.
- Comparison of survival curves between 104 depressed patients receiving treatment and non-depressed patients.
Main Results:
- Patients with liver transplants receiving depression treatment demonstrated improved median survival durations.
- Survival curves and hazard functions were more favorable for depressed patients undergoing treatment, even after controlling for age and prolonged survival.
Conclusions:
- Treatment for depression in liver transplant patients is associated with better survival outcomes.
- Seeking and receiving depression treatment may indicate better adherence to overall post-transplant medical regimens.
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