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Related Experiment Videos

[Polyclonal B-cell activation by so-called immunopotentiation (immunostimulants)].

J Kekow1, G Hobusch, J Lüdemann

  • 1I. Medizinische Universitätsklinik Kiel.

Deutsche Medizinische Wochenschrift (1946)
|July 14, 1989
PubMed
Summary

Bacterial preparations like OK 432 and Biostim showed potential for B-cell differentiation, but did not induce polyclonal B-cell activation in vitro. Further in vivo studies are suggested for these immuno-augmenting substances.

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Area of Science:

  • Immunology
  • Microbiology

Background:

  • Bacterial substances are explored for immuno-augmentation.
  • Polyclonal B-cell activation is a key immune response.

Purpose of the Study:

  • To evaluate bacterial preparations for polyclonal B-cell activation in vitro.
  • To compare their effects with known B-cell activators.

Main Methods:

  • In vitro study of bacterial preparations (Biostim, Broncho-Vaxom, Omnadin, Paspat, OK 432).
  • Assessed B-cell mitogenicity via 3H-thymidine incorporation.
  • Measured T-cell dependent and independent B-cell differentiation and immunoglobulin production.

Main Results:

  • None of the bacterial preparations induced B-cell mitogenicity.

Related Experiment Videos

  • OK 432 induced T-cell dependent B-cell differentiation.
  • Biostim induced T-cell independent B-cell differentiation, but with less immunoglobulin production than KlebsM.

    • Conclusions:

    • Bacterial preparations may induce B-cell differentiation, not necessarily polyclonal activation.
    • In vivo studies are warranted to confirm potential immuno-augmenting effects.