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Linc-ROR and its spliced variants 2 and 4 are significantly up-regulated in esophageal squamous cell carcinoma

Reza Sahebi1, Mahshid Malakootian2, Baharak Balalaee1

  • 1Department of Molecular Genetics, Faculty of Biological Sciences, Tarbiat Modares University, Tehran, Iran.

Iranian Journal of Basic Medical Sciences
|November 23, 2016
PubMed
Abstract

Insights

Long non-coding RNA ROR (linc-ROR) and its variants are significantly upregulated in esophageal squamous cell carcinoma (ESCC). This suggests linc-ROR may play a role in ESCC development and progression.

Area of Science:

  • Molecular biology
  • Cancer research
  • Epigenetics

Background:

  • Cellular reprogramming shares molecular pathways with tumorigenesis.
  • Yamanaka factors (OCT4, SOX2, KLF4, c-MYC) are oncogenes involved in cancer.
  • Long non-coding RNAs (lncRNAs) regulate stemness, reprogramming, and cancer.

Purpose of the Study:

  • Investigate the expression of lincRNA-ROR and its variants in esophageal squamous cell carcinoma (ESCC).
  • Determine the correlation between linc-ROR expression and tumor grade.
  • Assess the diagnostic potential of linc-ROR variants in ESCC.

Main Methods:

  • Quantitative real-time RT-PCR was used to analyze linc-ROR and its spliced variants (2 and 4) expression.
  • Expression levels were compared between ESCC tumor tissues and matched non-tumor tissues.
  • Receiver Operating Characteristic (ROC) curve analysis was performed.

Main Results:

  • linc-ROR and its variants 2 and 4 were significantly upregulated in ESCC tumors compared to non-tumor tissues.
  • Variant 4 showed significant upregulation in high-grade ESCC tumors.
  • ROC analysis indicated variant 4 can discriminate between tumor and non-tumor samples.

Conclusions:

  • linc-ROR and its variants 2 and 4 are significantly upregulated in ESCC.
  • linc-ROR variant 4 may serve as a potential biomarker for ESCC diagnosis and grading.
Keywords:
Esophageal squamous - cell carcinomaLinc-RORNon-coding RNASpliced variants

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