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Resistance to Non-glycopeptide Agents in Serious Staphylococcus aureus Infections

Kyle C Molina1, Vanthida Huang2

  • 1Department of Pharmacy Practice, College of Pharmacy-Glendale, Midwestern University, 19555 N. 59th Ave., Glendale, AZ, 85308, USA.

Current Infectious Disease Reports
|November 23, 2016
PubMed

Insights

Vancomycin is failing against serious Staphylococcus aureus infections. Alternative non-glycopeptide antibiotics show low resistance rates, but monitoring is crucial.

Area of Science:

  • Infectious Diseases
  • Microbiology
  • Pharmacology

Background:

  • Vancomycin's effectiveness against serious Staphylococcus aureus infections, including methicillin-resistant strains (MRSA), is declining due to rising Minimum Inhibitory Concentrations (MICs) and treatment failures.
  • Increasing reduced susceptibility of S. aureus to glycopeptides necessitates a reevaluation of alternative, non-glycopeptide therapeutic options.

Approach:

  • Review of large-scale surveillance programs and published literature on S. aureus resistance patterns.
  • Focus on non-glycopeptide antimicrobials such as daptomycin, ceftaroline, tigecycline, linezolid, and tedizolid.

Key Points:

  • Worldwide resistance rates to key non-glycopeptide antibiotics against serious MRSA infections remain low.
  • Surveillance data indicates continued efficacy for alternative therapies when vancomycin susceptibility is compromised.

Conclusions:

  • Continued monitoring of resistance trends for non-glycopeptide antimicrobials is essential as their use increases.
  • Implementation of robust antimicrobial stewardship programs is critical to preserve the effectiveness of these alternative agents against S. aureus.
Keywords:
DaptomycinLinezolidMethicillin-resistant S. Aureus (MRSA)OxazolidinoneTedizolidVancomycin

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