Related Experiment Videos
Blastogenic responses of human lymphocytes to a streptococcal preparation OK-432 and its fractions
13rd Department of Internal Medicine, Mie University School of Medicine, Tsu, Japan.
Journal of Clinical & Laboratory Immunology
|February 1, 1989
Abstract:
This study was undertaken to examine the blastogenic responses of PBL to Streptococcal preparation OK-432 and its fractions. The results showed that OK-432 and its fractions, Su-PR and PM, have the mitogenic activity against human lymphocytes. The demonstration that PBL which had been cultured with OK-432 expressed IL-2 receptors and the blastogenic responses of PBL to OK-432 were inhibited by anti-IL-2 antibody suggested that IL-2 and IL-2 receptors might play a central role in OK-432-induced proliferation of human lymphocytes.