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Squamous Cell Carcinoma of the Bladder: A SEER Database Analysis
1Clinical Oncology Department, Faculty of Medicine, Ain Shams University, Cairo, Egypt.
Clinical Genitourinary Cancer
|November 24, 2016
Summary
Radical surgery improves survival for nonmetastatic squamous cell carcinoma (SCC) of the bladder compared to radiation therapy. Further trials are needed for bladder-preserving options in SCC management.
Area of Science:
- Urology
- Oncology
- Epidemiology
Background:
- Limited evidence exists on managing bladder squamous cell carcinoma (SCC).
- This study examines epidemiological and treatment trends for bladder SCC.
Purpose of the Study:
- To assess the incidence and treatment outcomes of bladder SCC.
- To compare the effectiveness of radical surgery versus radiation therapy for nonmetastatic bladder SCC.
Main Methods:
- Utilized the Surveillance, Epidemiology, and End Results (SEER) database (1973-2013).
- Conducted propensity-score matching for nonmetastatic patients.
- Performed survival analysis using Kaplan-Meier methods.
Main Results:
- Identified 5018 bladder SCC cases; incidence decreased from 1973-2013.
- Radical surgery significantly improved cancer-specific and overall survival versus radiation or no treatment (P < .0001).
- Survival benefit of surgery was consistent across localized and regional SEER stages.
Conclusions:
- Radical surgery offers superior outcomes for nonmetastatic bladder SCC compared to radiation therapy.
- Further prospective trials are recommended for bladder-preserving protocols in this subtype.
