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Related Experiment Videos

The leukocyte integrins.

N Hogg

    Immunology Today
    |April 1, 1989
    PubMed
    Summary
    This summary is machine-generated.

    Patients with recurrent bacterial infections were found to have neutrophils with reduced surface spreading. These individuals, diagnosed with leukocyte adhesion deficiency (LAD), lacked key leukocyte integrin molecules, prompting dedicated research meetings.

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    Area of Science:

    • Immunology
    • Cell Biology
    • Hematology

    Background:

    • Recurrent bacterial infections in some patients were linked to neutrophil dysfunction.
    • Neutrophils from affected individuals exhibited impaired spreading on surfaces.
    • This dysfunction was associated with a deficiency in specific cell surface molecules.

    Purpose of the Study:

    • To identify the molecular basis of a specific neutrophil defect.
    • To characterize patients with recurrent infections and impaired neutrophil function.
    • To establish a research focus on leukocyte adhesion deficiency.

    Main Methods:

    • Clinical observation of patients with recurrent bacterial infections.
    • Analysis of neutrophil behavior, specifically surface spreading.

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  • Identification of deficient cell surface molecules on leukocytes.

    • Main Results:

    • A rare group of patients with recurrent bacterial infections was identified.
    • These patients' neutrophils demonstrated reduced spreading capabilities.
    • The deficiency was attributed to a lack of molecules within the leukocyte integrin family (LFA-1, CR3, p150,95/CR4, or CD11/CD18).

    Conclusions:

    • Leukocyte adhesion deficiency (LAD) is a condition characterized by impaired neutrophil function.
    • The deficiency in specific leukocyte integrins underlies LAD.
    • The identification of LAD spurred dedicated scientific inquiry, marked by the first dedicated meeting in 1988.