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Interaction between excess folate and low vitamin B12 status.
1Jean Mayer USDA Human Nutrition Research Center for Aging at Tufts University, Boston, MA, 02111, USA.
High folate and low vitamin B12 status is linked to adverse health outcomes in children, older adults, and pregnant women. This review examines the interplay between folate and vitamin B12 and their health impacts.
Area of Science:
- Nutrition Science
- Public Health
- Gerontology
Background:
- Epidemiological data indicate that a nutritional imbalance, specifically high folate status coupled with low vitamin B12 status, is associated with adverse health outcomes.
- This imbalance during pregnancy poses risks for maternal diabetes and for offspring, including insulin resistance, adiposity, and low birthweight.
Purpose of the Study:
- To review current knowledge on the interaction between folate and vitamin B12.
- To summarize the associated health outcomes in different populations.
Main Methods:
- Literature review of epidemiological evidence.
- Synthesis of current research on folate and vitamin B12 interactions.
Main Results:
- Vitamin B12 absorption can decrease in older adults due to aging, leading to low status despite adequate intake.
- Folic acid exposure varies for pregnant women globally, influencing nutritional status.
- The interaction between folate and vitamin B12 significantly impacts health across the lifespan.
Conclusions:
- Maintaining optimal folate and vitamin B12 status is crucial for preventing negative health outcomes.
- Understanding this nutrient interaction is vital for public health strategies, particularly for vulnerable populations like pregnant women and older adults.
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