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Bradykinin blocks the action of EGF, but not PDGF, on fibroblast division
E L Newman1, L Hyldahl, O Larsson
1Laboratory of Molecular Biophysics, University of Oxford, England.
FEBS Letters
|July 17, 1989
Abstract:
Quiescent fibroblasts derived from human fetal lung can be stimulated to reinitiate DNA synthesis by sequential addition of 3 nM IGF-1 and a low concentration (8 pM) of EGF or by continuous exposure to 10% fetal calf serum or 10 ng/ml PDGF. Bradykinin blocks the IGF-1 and EGF-dependent signals without affecting the response to serum or PDGF. It activates protein kinase C and its anti-mitogenic effect is abolished after this kinase has been down-regulated. Bradykinin has no effect on the binding affinity of the EGF receptor whereas phorbol ester induces its 'transmodulation' to low affinity.