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Microvesicles as Vehicles for Tissue Regeneration: Changing of the Guards

Nikolaos Panagiotou1, R Wayne Davies2, Colin Selman3

  • 1Wolfson Wohl, Translational Research Centre, Institute of Cancer Sciences, MVLS, University of Glasgow, Garscube Estate, Switchback Road, Glasgow, G61 1QH UK.

Current Pathobiology Reports
|November 25, 2016
PubMed
Abstract

Insights

Microvesicles (MVs) mediate stem cell function for tissue repair. Understanding MVs may lead to cell-free therapeutics for age-related diseases.

Area of Science:

  • Cell Biology
  • Regenerative Medicine

Background:

  • Microvesicles (MVs) are key mediators of stem cell function, facilitating cell-to-cell communication through the transfer of proteins, mRNA, and microRNA (miRNA).
  • Stem cell-derived MVs play established roles in tissue regeneration and repair.

Approach:

  • This review critically evaluates recent research on microvesicle biogenesis and mechanisms of action.
  • Highlights new findings on the application of MVs in tissue regeneration.

Key Points:

  • Microvesicles (MVs) are a distinct class of extracellular vesicles (EVs) released from the plasma membrane.
  • MVs facilitate intercellular communication by transferring molecular cargo.
  • The role of MVs in maintaining healthy tissue function and age-related health span requires further elucidation.

Conclusions:

  • Understanding MV mechanisms can lead to cell-free therapeutics for age-related degenerative diseases.
  • MVs show promise in tissue maintenance and repair applications.
Keywords:
AgeingMicrovesiclesRegenerative medicineStem cellsTissue regenerationextracellular vesicles

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