Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Diversity in Cell Signaling Responses01:22

Diversity in Cell Signaling Responses

6.5K
The physiological function of a cell and cellular communication are outcomes of a range of extrinsic signals, intracellular signaling pathways, and cellular responses. No two cell types express the same repertoire of signaling components. Receptors are highly selective for their cognate ligands, but once activated, they can alter multiple cellular processes such as DNA transcription, protein synthesis, and metabolic activity. 
Graded and Abrupt Responses
Some signaling systems generate...
6.5K
Interactions Between Signaling Pathways01:19

Interactions Between Signaling Pathways

6.3K
Signaling cascades usually lack linearity. Multiple pathways interact and regulate one another, allowing cells to integrate and respond to diverse environmental stimuli.
Convergence and divergence, and cross-talk between signaling pathways
Two distinct signaling pathways can converge on a single functional unit, which may either be a single protein or a complex of proteins. The response is either functionally distinct or synergistic between the two pathways but different from the response...
6.3K
Amplifying Signals via Enzymatic Cascade01:22

Amplifying Signals via Enzymatic Cascade

8.6K
When a ligand binds to a cell-surface receptor, the receptor's intracellular domain changes shape, which may either activate its enzyme function or allow its binding to other molecules. The initial signal is amplified by most signal transduction pathways. This means that a single ligand molecule can activate multiple molecules of a downstream target. Proteins that relay a signal are most commonly phosphorylated at one or more sites, activating or inactivating the protein. Kinases catalyze...
8.6K
Intracellular Signaling Cascades01:24

Intracellular Signaling Cascades

47.2K
Once a ligand binds to a receptor, the signal is transmitted through the membrane and into the cytoplasm. The continuation of a signal in this manner is called signal transduction. Signal transduction only occurs with cell-surface receptors, which cannot interact with most components of the cell, such as DNA. Only internal receptors can interact directly with DNA in the nucleus to initiate protein synthesis. When a ligand binds to its receptor, conformational changes occur that affect the...
47.2K
Cell Signaling Feedback Loops01:07

Cell Signaling Feedback Loops

6.4K
Positive and negative feedback loops are crucial for regulating biological signaling systems. These feedback loops are processes that connect output signals to their inputs.
Negative feedback loops
Most signaling systems have negative feedback loops that can perform different functions such as output limiter, and adaptation.
Output limiter
Upon receiving an input signal, the cellular response rapidly increases until a threshold is reached. Beyond this threshold, a negative feedback loop...
6.4K
Signal Transduction: Overview01:26

Signal Transduction: Overview

8.6K
Cells respond to many types of information, often through receptor proteins positioned on the membrane. They respond to chemical signals, such as hormones, neurotransmitters, and other signaling molecules, initiating a series of molecular reactions to produce an appropriate response. This is called signal transduction. Cells also coordinate different responses elicited by the same signaling molecule via mediators, allowing molecular cross-talk.
Typically, signal transduction involves three...
8.6K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Aggregation Methods for Quantifying PTM and Structural Changes in Bottom-Up Proteomics.

Journal of proteome research·2026
Same author

A standardized workflow for kinetic metabolic model curation and dissemination.

PLoS computational biology·2026
Same author

Antimony 3: Extending human-readable model definitions for SBML Level 3 Core and Packages.

bioRxiv : the preprint server for biology·2026
Same author

Urbanization intensified the risks of neonicotinoids to estuarine and marine ecosystems under a backdrop of agricultural cultivation.

Environmental pollution (Barking, Essex : 1987)·2026
Same author

Thiol post-translational modifications modulate allosteric regulation of the OpcA-G6PDH complex through conformational gate control.

Protein science : a publication of the Protein Society·2026
Same author

Chromosome-level genome assembly and annotation of the moon jellyfish Aurelia coerulea.

Scientific data·2026
Same journal

Advances in PET Diagnostics for Guiding Targeted Cancer Therapy and Studying In Vivo Cancer Biology.

Current pathobiology reports·2023
Same journal

Clinical Applications of Bone Tissue Engineering in Orthopedic Trauma.

Current pathobiology reports·2022
Same journal

Chemokine-Based Therapeutics for the Treatment of Inflammatory and Fibrotic Convergent Pathways in COVID-19.

Current pathobiology reports·2021
Same journal

The Pathobiological Basis for Thrombotic Complications in COVID-19: a Review of the Literature.

Current pathobiology reports·2021
Same journal

Toxicology of Nanoparticles in Drug Delivery.

Current pathobiology reports·2021
Same journal

Acceleration of PDE-Based Biological Simulation Through the Development of Neural Network Metamodels.

Current pathobiology reports·2021
See all related articles

Related Experiment Video

Updated: Aug 5, 2025

Light-mediated Reversible Modulation of the Mitogen-activated Protein Kinase Pathway during Cell Differentiation and Xenopus Embryonic Development
09:32

Light-mediated Reversible Modulation of the Mitogen-activated Protein Kinase Pathway during Cell Differentiation and Xenopus Embryonic Development

Published on: June 15, 2017

8.8K

Dynamics and Sensitivity of Signaling Pathways.

Michael A Kochen1, Steven S Andrews1, H Steven Wiley2

  • 1Department of Bioengineering, University of Washington, Seattle, WA, USA.

Current Pathobiology Reports
|March 27, 2023
PubMed
Summary
This summary is machine-generated.

Signaling pathway models can help identify cancer drug targets by pinpointing key molecular parameters. This approach aids in developing more effective cancer therapeutics by understanding cellular communication networks.

Keywords:
CancerDynamicsSensitivitySignaling networks

More Related Videos

Spatiotemporal Control of Protein Activity through Optogenetic Allosteric Regulation
08:00

Spatiotemporal Control of Protein Activity through Optogenetic Allosteric Regulation

Published on: October 4, 2024

648
Author Spotlight: Manipulating Signaling in Zebrafish Embryos to Decode Cell Fate Decisions
07:18

Author Spotlight: Manipulating Signaling in Zebrafish Embryos to Decode Cell Fate Decisions

Published on: October 27, 2023

2.6K

Related Experiment Videos

Last Updated: Aug 5, 2025

Light-mediated Reversible Modulation of the Mitogen-activated Protein Kinase Pathway during Cell Differentiation and Xenopus Embryonic Development
09:32

Light-mediated Reversible Modulation of the Mitogen-activated Protein Kinase Pathway during Cell Differentiation and Xenopus Embryonic Development

Published on: June 15, 2017

8.8K
Spatiotemporal Control of Protein Activity through Optogenetic Allosteric Regulation
08:00

Spatiotemporal Control of Protein Activity through Optogenetic Allosteric Regulation

Published on: October 4, 2024

648
Author Spotlight: Manipulating Signaling in Zebrafish Embryos to Decode Cell Fate Decisions
07:18

Author Spotlight: Manipulating Signaling in Zebrafish Embryos to Decode Cell Fate Decisions

Published on: October 27, 2023

2.6K

Area of Science:

  • Cellular signaling and cancer biology
  • Computational systems biology

Background:

  • Signaling pathways transmit extracellular information to control cell responses.
  • Mutations in signaling networks are linked to uncontrolled cell growth and cancer.
  • Signaling proteins are crucial therapeutic targets in oncology.

Purpose of the Study:

  • To review the utility of signaling pathway modeling in identifying effective cancer drugs.
  • To highlight the importance of identifying controlling biochemical parameters for therapeutic intervention.

Main Methods:

  • Summarizing current understanding of phosphorylation cycle sensitivity.
  • Describing properties of regulatory motifs like feedback and feedforward loops.

Main Results:

  • Discusses the sensitivity of phosphorylation cycles.
  • Explains regulatory motifs in signaling networks.

Conclusions:

  • There is a need for more scalable signaling network models.
  • Models should represent complexity across diverse cell types and tumors.