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Updated: Feb 10, 2026

Implantation of Total Artificial Heart in Congenital Heart Disease
Published on: July 17, 2014
A lncRNA Perspective into (Re)Building the Heart
Stefan Frank1, Aitor Aguirre2, Juergen Hescheler3
1Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases, University of CologneCologne, Germany; Institute for Neurophysiology, University of CologneCologne, Germany; Center for Molecular Medicine (CMMC), University of CologneCologne, Germany.
Long non-coding RNAs (lncRNAs), once overlooked, are now recognized for their crucial roles in heart development and homeostasis. This review highlights recent advances in understanding lncRNA functions in cardiac repair and regeneration.
Area of Science:
- Genomics
- Molecular Biology
- Cardiovascular Research
Background:
- The human genome's function extends beyond protein-coding genes, with a significant portion transcribed into non-coding RNAs.
- Long non-coding RNAs (lncRNAs) are increasingly recognized for their roles in cellular functions, particularly in development and tissue maintenance.
- The specific involvement of lncRNAs in cardiac biology, especially during development and in response to injury, is an active area of research.
Conclusions:
- The non-coding portion of the genome, particularly lncRNAs, plays a vital role in cardiovascular health.
- Understanding lncRNA mechanisms offers new avenues for therapeutic interventions in heart disease.
- Further research into lncRNAs is essential for advancing cardiac regenerative medicine.
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