Related Experiment Video
Updated: Aug 14, 2026

Noninvasive Sampling of Mucosal Lining Fluid for the Quantification of In Vivo Upper Airway Immune-mediator Levels
Published on: August 7, 2017
[Characteristics of local immunity in newborn infants]
Abstract:
The secretory immune system was found to be different in neonates and their mothers. The differences manifested in the low content of IgA and high content of the free secretory component in the child's saliva and tears as well as in neonatal milk. In order to study the local immunity of neonates, use was made of neonatal milk as a research object. The system of the complement C3-component synthesis on the mucous membranes appeared mature even in the neonatal period. Based on a comparative analysis of the subpopulations of the immunocompetent cells of blood and milk of neonates and their mothers the conclusion is made about the activation in the neonatal period of the immune system of the mucous membranes associated with the low functional activity of the systemic immunity. The comparative analysis of the immunosuppressive properties of the breast and neonatal milk has demonstrated that the low suppressor activity of secretory factors of the neonates' mucous membranes may be one of the causes of the local immunity activation.
Related Concept Videos
Defense Mechanism Against Infection
In addition, many body organ systems have unique defenses against infection. The skin is an intact, multilayered surface preventing invasion by microorganisms unless impaired. Mucous membranes lining the mouth, nose, and eyelids are barriers...
Introduction to Lymphatic and Immune System
The immune responses can be categorized into two types: innate and adaptive. Innate immunity comprises nonspecific defenses we are born...
Introduction to Innate and Adaptive Immunity
Innate immunity is the body's natural, nonspecific defense system that acts quickly to protect against pathogens. It incorporates physical barriers like skin and mucous membranes and cellular elements such as phagocytes and natural killer cells. This part of our immune system provides an immediate,...
Special Features of Adaptive Immunity
The primary cell types involved in adaptive immunity are T cells and B cells. Each type has a unique role in defending the body against pathogens. T cells are responsible for cell-mediated immunity. They identify and eliminate infected cells directly,...
Immunological Memory
What is Immunological Memory?
Immunological memory is an integral function of the immune system that allows it to recognize and react more rapidly and effectively to pathogens previously encountered. This feature is...
Development of Immunocompetence
The initial cells that migrate from the fetal thymus settle within the skin and epithelial tissues lining the mouth, digestive tract, and in females, the uterus and vagina. These cells, including skin-based dendritic cells, serve as antigen-presenting cells, playing a key role in T cell activation.
Subsequent T...

