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Microfluidic PDMS on paper (POP) devices.

Jin-Wen Shangguan1, Yu Liu1, Jian-Bin Pan1

  • 1State Key Laboratory of Analytical Chemistry for Life Science and Collaborative Innovation Center of Chemistry for Life Sciences, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210023, China. xujj@nju.edu.cn.

Lab on a Chip
|November 25, 2016
PubMed
Summary
This summary is machine-generated.

We developed novel microfluidic polydimethylsiloxane (PDMS) on paper (POP) devices by optimizing PDMS patterning for rapid, accurate integration. These versatile POP devices enable complex lab-on-a-chip applications, including liver function marker analysis.

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Area of Science:

  • Microfluidics
  • Biomedical Engineering
  • Materials Science

Background:

  • Paper-based microfluidic devices offer low cost and portability.
  • Polydimethylsiloxane (PDMS) microfluidic devices provide excellent biocompatibility and fabrication flexibility.
  • Integrating paper and PDMS presents challenges in achieving reliable and precise interfaces.

Purpose of the Study:

  • To propose a generalized concept for microfluidic polydimethylsiloxane (PDMS) on paper (POP) devices.
  • To optimize PDMS spatial patterning on paper for rapid and accurate fabrication.
  • To demonstrate the versatility of POP devices for complex analytical applications.

Main Methods:

  • Optimized screen printing and high-temperature, superfast curing for PDMS patterning on paper (tens of microns accuracy in <10 seconds).
  • Developed a method for seamless, reversible integration of patterned PDMS with paper layers.
  • Constructed a prototype POP device for colorimetric analysis of liver function markers (ALP, AST).

Main Results:

  • Achieved accurate PDMS patterning on paper in under ten seconds.
  • Successfully integrated porous paper and smooth PDMS channels within a single device.
  • Demonstrated quantitative sample loading, mixing, and multiplex analysis on the prototype POP device for liver function markers.

Conclusions:

  • The proposed generalized concept of POP devices offers enhanced design flexibility by combining paper and PDMS functionalities.
  • The optimized fabrication technique enables rapid and precise integration, paving the way for complex microfluidic systems.
  • POP devices show significant potential for point-of-care diagnostics and other lab-on-a-chip applications, exemplified by liver function marker analysis.