Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Development of the Sexual Organs in the Embryo and Fetus01:15

Development of the Sexual Organs in the Embryo and Fetus

4.5K
Development of the reproductive organs in an embryo starts from a bipotential state. This means the early embryo can develop either male or female reproductive organs. The formation of these organs begins with the growth of gonadal ridges that arise from the intermediate mesoderm during the fifth week of development.
Near the gonadal ridges, two duct systems are present: the mesonephric ducts (Wolffian ducts) and paramesonephric ducts (Müllerian ducts). These ducts form the basis for the...
4.5K
Accessory Glands of the Male Reproductive System01:16

Accessory Glands of the Male Reproductive System

4.3K
The accessory ducts involved in sperm maturation and transportation include the epididymides, vasa deferentia, ejaculatory ducts, and urethra. These ducts play a critical role in the maturation, storage, and transportation of sperm from the testes to the urethra, where it is then released during ejaculation.
The epididymis is a small, comma-shaped organ located at the back of each testicle. The epididymis can be divided into three main parts: the head, body, and tail. The head of the epididymis...
4.3K
Accessory Ducts of the Male Reproductive System01:25

Accessory Ducts of the Male Reproductive System

3.7K
The male reproductive system is a complex network of organs and tissues that work together to produce and transport sperm. The epididymis, vasa deferens, ejaculatory ducts, and urethra are the accessory ducts involved in sperm maturation and transportation. These ducts play a critical role in the production and transportation of sperm from the testes to the urethra, where it is then released during ejaculation.
The epididymis is a small, comma-shaped organ located at the back of each testicle....
3.7K
Non-Canonical Wnt Signaling Pathways01:41

Non-Canonical Wnt Signaling Pathways

8.5K
Wnt is a zygotic effect gene that is expressed during very early embryonic development. It regulates various processes in animals starting from early development through the adult stage, such as organogenesis in the embryo and maintenance of neuronal and blood stem cells. Wnt proteins can induce a wide variety of intracellular pathways depending upon the specific abilities of different Wnt ligands to form a complex with shared and cognate receptors in the presence of different co-receptors. The...
8.5K
Hedgehog Signaling Pathway02:33

Hedgehog Signaling Pathway

10.3K
The Hedgehog gene (Hh) was first discovered due to its control of the growth of disorganized, hair-like bristles phenotype in Drosophila, much like hedgehog spines. Hh plays a crucial role in the development of organs and the maintenance of homeostasis in both invertebrates and vertebrates. However, while Drosophila has only one Hh protein, mammals have multiple functional Hedgehog proteins - Sonic (Shh), Desert (Dhh), and Indian Hedgehog (Ihh). All of these homologous proteins have adapted to...
10.3K
Canonical Wnt Signaling Pathway02:54

Canonical Wnt Signaling Pathway

10.9K
The gene encoding the main signaling molecules of the Wnt signaling pathways (the Wnt proteins) was discovered almost four decades ago by Nüsslein-Volhard and Wieschaus. They identified and originally named the gene "wingless" (wg) after a phenotype discovered during their landmark genetic screen in Drosophila for body pattern defects. At around the same time, another researcher named Harold Varmus found that a murine tumor virus activates the mammalian wg homolog, Int-1, which...
10.9K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Social and Anxiety-Like Behaviors Are Affected in Juvenile Mice With Gli2<sup>+/-</sup> but Not Gli3<sup>+/𝛥699</sup> Genetic Modifications.

Brain and behavior·2026
Same author

Biomechanic characterization of normal urethra using uro-dynamic MRI during voiding.

International urology and nephrology·2026
Same author

Quantitative Mechanics of the Bladder During Voiding Using MRI.

Neurourology and urodynamics·2025
Same author

Computational fluid dynamics of bladder voiding using 3D dynamic MRI.

International journal for numerical methods in biomedical engineering·2024
Same author

Validation of Dynamic 3D MRI for Urodynamics Assessment Using an Anatomically Realistic In Vitro Model of the Bladder.

Journal of biomechanical engineering·2024
Same author

Technical feasibility of uro-dynamic MRI study of voiding biomechanics: a pilot study.

International urology and nephrology·2023
Same journal

Multi-stage transcriptome analysis reveals genetic orchestration of rat testis development.

Developmental dynamics : an official publication of the American Association of Anatomists·2026
Same journal

Three-dimensional observation of the muscle-tendon integration process in mouse embryos.

Developmental dynamics : an official publication of the American Association of Anatomists·2026
Same journal

Goofy/123Cre lineage tracing differentiates olfactory and vomeronasal neurons from GnRH-1 and terminal nerve neurons during neuronal migration and reveals additional olfactory placode-derived cells in the brain.

Developmental dynamics : an official publication of the American Association of Anatomists·2026
Same journal

Prenatal sexual dimorphism in human pelvic tilt at the onset of fetal ossification.

Developmental dynamics : an official publication of the American Association of Anatomists·2026
Same journal

Meet the editorial team. An interview with Ralph Marcucio, Assistant Editor, University of California San Francisco, United States.

Developmental dynamics : an official publication of the American Association of Anatomists·2026
Same journal

Editorial highlights.

Developmental dynamics : an official publication of the American Association of Anatomists·2026
See all related articles

Related Experiment Video

Updated: Mar 11, 2026

Evaluating the Differentiation Capacity of Mouse Prostate Epithelial Cells Using Organoid Culture
10:38

Evaluating the Differentiation Capacity of Mouse Prostate Epithelial Cells Using Organoid Culture

Published on: November 22, 2019

9.6K

Morphoregulatory pathways in prostate ductal development.

Monica Montano1,2,3, Wade Bushman1,3

  • 1University of Wisconsin Madison, Department of Urology, Madison, Wisconsin.

Developmental Dynamics : an Official Publication of the American Association of Anatomists
|November 25, 2016
PubMed
Summary
This summary is machine-generated.

This review details mouse prostate development, focusing on genetic regulators and signaling pathways. It also highlights the extracellular matrix (ECM) role in development and prostate cancer prognosis.

Keywords:
HedgehogHoxNkx3.1NotchSox9TGFβ/BMPWntandrogen receptorextracellular matrixfibroblast growth factorprostate development

More Related Videos

Identification, Histological Characterization, and Dissection of Mouse Prostate Lobes for In Vitro 3D Spheroid Culture Models
08:43

Identification, Histological Characterization, and Dissection of Mouse Prostate Lobes for In Vitro 3D Spheroid Culture Models

Published on: September 18, 2018

22.3K
Murine Prostate Micro-dissection and Surgical Castration
08:49

Murine Prostate Micro-dissection and Surgical Castration

Published on: May 11, 2016

48.0K

Related Experiment Videos

Last Updated: Mar 11, 2026

Evaluating the Differentiation Capacity of Mouse Prostate Epithelial Cells Using Organoid Culture
10:38

Evaluating the Differentiation Capacity of Mouse Prostate Epithelial Cells Using Organoid Culture

Published on: November 22, 2019

9.6K
Identification, Histological Characterization, and Dissection of Mouse Prostate Lobes for In Vitro 3D Spheroid Culture Models
08:43

Identification, Histological Characterization, and Dissection of Mouse Prostate Lobes for In Vitro 3D Spheroid Culture Models

Published on: September 18, 2018

22.3K
Murine Prostate Micro-dissection and Surgical Castration
08:49

Murine Prostate Micro-dissection and Surgical Castration

Published on: May 11, 2016

48.0K

Area of Science:

  • Developmental Biology
  • Urology
  • Molecular Biology

Background:

  • The mouse prostate, a male sex-accessory gland, features a branched ductal network across three lobes: anterior, dorsolateral, and ventral.
  • Prostate ductal development is a key morphogenetic event requiring intricate spatiotemporal regulation.

Purpose of the Study:

  • To provide an overview of prostate development, including major genetic regulators and signaling pathways.
  • To identify understudied areas, specifically the role of the extracellular matrix (ECM) in prostate development.
  • To explore the potential impact of the ECM on prostate cancer behavior and prognosis.

Main Methods:

  • Literature review synthesizing current knowledge on prostate development.
  • Analysis of genetic and signaling pathway involvement.
  • Exploration of the extracellular matrix's role based on existing research.

Main Results:

  • Key genetic regulators and signaling pathways governing prostate ductal development are identified.
  • The extracellular matrix (ECM) is highlighted as a potentially significant but understudied factor in prostate development.
  • The ECM's influence on prostate cancer progression and patient outcomes is suggested.

Conclusions:

  • Understanding prostate development requires knowledge of genetic and signaling pathways.
  • The extracellular matrix (ECM) warrants further investigation for its role in normal prostate development and cancer.
  • ECM interactions may be crucial for predicting prostate cancer prognosis.