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Obesity: A Perspective from Hypertension

Dinko Susic1, Jasmina Varagic2

  • 1Hypertension Research Laboratory, Ochsner Clinic Foundation, 1514 Jefferson Highway New Orleans, Louisiana 70121, USA.

The Medical Clinics of North America
|November 26, 2016
PubMed

Insights

Obesity-related hypertension is a significant global health concern. Understanding its complex mechanisms is crucial for developing effective treatment strategies for obese individuals with high blood pressure.

Area of Science:

  • Cardiology
  • Endocrinology
  • Nephrology

Background:

  • Obesity-related hypertension is a prevalent worldwide health issue.
  • The intricate mechanisms linking obesity and hypertension are under extensive investigation.
  • These mechanisms involve multiple interacting factors, highlighting the complexity of the condition.

Purpose of the Study:

  • To review the multifactorial mechanisms contributing to obesity-related hypertension.
  • To emphasize the need for recognizing obesity-related hypertension as a distinct hypertensive condition.
  • To inform therapeutic approaches for managing high blood pressure in obese individuals.

Main Methods:

  • Literature review of current research on obesity and hypertension.
  • Analysis of physiological and pathophysiological pathways involved.
  • Synthesis of evidence on interacting factors.

Main Results:

  • Key mechanisms include altered hemodynamics, impaired sodium balance, renal dysfunction, autonomic imbalance, endocrine changes, oxidative stress, inflammation, and vascular injury.
  • These factors interact dynamically, underscoring the multifactorial nature of the disease.
  • Obesity-induced changes contribute significantly to the development and maintenance of hypertension.

Conclusions:

  • Obesity-related hypertension is a complex, multifactorial condition requiring specific recognition.
  • Therapeutic strategies must consider the unique interplay of factors in obese hypertensive patients.
  • Further research is needed to fully elucidate and target these mechanisms for improved patient outcomes.

Keywords:
AdipokinesHypertensionInsulin resistanceObesityRenin-angiotensin-aldosterone systemSodiumSympathetic nervous system

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