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Updated: Mar 11, 2026

Optogenetic Manipulation of Neural Circuits During Monitoring Sleep/wakefulness States in Mice
Published on: June 19, 2019
Sleep & metabolism: The multitasking ability of lateral hypothalamic inhibitory circuitries
Carolina Gutierrez Herrera1, Alexey Ponomarenko2, Tatiana Korotkova2
1Department of Neurology and Department of Clinical Research, Inselspital University Hospital, University of Bern, Bern, Switzerland; Department of Psychiatry, McGill University, Montreal, QC, Canada.
Abstract:
The anatomical and functional mapping of lateral hypothalamic circuits has been limited by the numerous cell types and complex, yet unclear, connectivity. Recent advances in functional dissection of input-output neurons in the lateral hypothalamus have identified subset of inhibitory cells as crucial modulators of both sleep-wake states and metabolism. Here, we summarize these recent studies and discuss the multi-tasking functions of hypothalamic circuitries in integrating sleep and metabolism in the mammalian brain.
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