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Updated: Mar 11, 2026
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Generation of Cationic Nanoliposomes for the Efficient Delivery of In Vitro Transcribed Messenger RNA
Published on: February 1, 2019
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Biodegradable nano-polymers as delivery vehicles for therapeutic small non-coding ribonucleic acids
Ahad Mokhtarzadeh1, Abbas Alibakhshi2, Maryam Hashemi3
1Research Center for Pharmaceutical Nanotechnology, Tabriz University of Medical Sciences, Tabriz, Iran; Department of Biotechnology, Higher Education Institute of Rab-Rashid, Tabriz, Iran.
Summary
Small non-coding RNAs (sncRNAs) regulate genes and treat diseases. This review highlights biodegradable biopolymers for safe and effective in vivo delivery of sncRNAs, overcoming major limitations in RNA interference therapy.
Area of Science:
- Biochemistry
- Molecular Biology
- Biotechnology
Background:
- Small non-coding RNAs (sncRNAs) are crucial for gene regulation and have therapeutic potential for various diseases, including cancer and metabolic disorders.
- Effective in vivo delivery remains a significant challenge for RNA interference (RNAi) therapies, hindering clinical applications.
- Safe and targeted delivery systems are essential for successful RNAi-based treatments.
Purpose of the Study:
- To review the functions of sncRNAs in biological processes.
- To explore recent advancements in the delivery of sncRNAs using biodegradable and biocompatible biopolymers.
- To address the limitations of current in vivo delivery methods for RNA interference technology.
Main Methods:
- Literature review focusing on sncRNA functions and delivery systems.
- Analysis of biodegradable, biocompatible, and non-toxic biopolymers for sncRNA delivery.
- Discussion of specific biopolymers such as chitosan, cyclodextrins, poly-l-lysine, dextran, PLGA, PGA, hyaluronic acid, and gelatin.
Main Results:
- sncRNAs play vital roles in gene regulation across numerous biological processes.
- Various biopolymers demonstrate potential as safe and effective carriers for in vivo sncRNA delivery.
- These materials offer controlled release and site-specific delivery, crucial for therapeutic efficacy.
Conclusions:
- Biodegradable biopolymers represent a promising solution for overcoming in vivo delivery challenges in RNA interference therapy.
- Further research into these materials can advance the clinical application of sncRNAs for treating diverse diseases.
- Optimized biopolymer-based delivery systems are key to unlocking the full therapeutic potential of sncRNAs.
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