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Updated: Mar 11, 2026

Mechanostimulation of Multicellular Organisms Through a High-Throughput Microfluidic Compression System
Published on: December 23, 2022
[Mechanotransduction and mechanical control of gene expression.]
Kota Miyasaka1, Atsushi Kubo1, Toshihiko Ogura1
1Department of Developmental Neurobiology, Institute of Development, Aging and Cancer, Tohoku University, Japan.
None:
Cells change gene expression when they differentiate into different cell lineages. Cells also change their gene expression profiles to adapt to altering milieus. Even physical forces(for example, forces evoked by muscle contraction or exercise)change gene expression dramatically, although the molecular mechanisms of this physico-genetic link are largely unknown. Here, we summarize several works published recently, trying to highlight the physical force as an essential parameter of gene expression and maintenance of homeostasis.
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