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In Vitro Thrombosis Test for Ventricular Assist Devices

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Thrombin-Responsive Transcutaneous Patch for Auto-Anticoagulant Regulation.

Yuqi Zhang¹, Jicheng Yu¹, Jinqiang Wang¹

¹Joint Department of Biomedical Engineering, University of North Carolina at Chapel Hill and North Carolina State University, Raleigh, NC 27695, USA.

Advanced Materials (Deerfield Beach, Fla.)

|November 26, 2016

Summary

This summary is machine-generated.

A novel microneedle patch delivers heparin in a closed-loop system, responding to thrombin levels to prevent blood clots. This smart patch offers controlled, prolonged anticoagulation therapy with minimal leakage.

Keywords:

anticoagulation closed-loop drug delivery heparin thrombin-responsive

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Area of Science:

Biomedical Engineering
Drug Delivery Systems
Biomaterials Science

Background:

Thrombin plays a crucial role in blood coagulation.
Current anticoagulation methods often lack precise control and can lead to bleeding risks.
Developing sophisticated drug delivery systems is essential for targeted and responsive therapies.

Purpose of the Study:

To develop a thrombin-responsive, closed-loop microneedle patch for controlled heparin delivery.
To create a "smart" patch capable of sensing thrombin and releasing heparin accordingly.
To enable sustained regulation of blood coagulation in response to physiological cues.

Main Methods:

Fabrication of a microneedle-based patch integrated with thrombin-sensing and heparin-releasing mechanisms.
In vitro and in vivo evaluation of the patch's responsiveness to thrombin.
Assessment of heparin release kinetics and anticoagulation efficacy.
Evaluation of transcutaneous insertion and drug leakage prevention.

Main Results:

The developed microneedle patch demonstrated effective thrombin sensing capabilities.
Heparin was released in a feedback-controlled manner in response to elevated thrombin levels.
The patch achieved prolonged and sustained regulation of blood coagulation.
Transcutaneous insertion prevented drug leakage and ensured localized delivery.

Conclusions:

A thrombin-responsive closed-loop microneedle patch for controlled heparin delivery has been successfully developed.
This "smart" patch offers a promising platform for advanced anticoagulation therapy.
The system provides localized, feedback-controlled drug delivery, enhancing therapeutic efficacy and safety.