Related Experiment Video
Updated: Mar 11, 2026

Heuristic Mining of Hierarchical Genotypes and Accessory Genome Loci in Bacterial Populations
Published on: December 7, 2021
Rapid scoring of genes in microbial pan-genome-wide association studies with Scoary
Ola Brynildsrud1, Jon Bohlin2, Lonneke Scheffer2,3
1Domain of Infectious Disease Control and Environmental Health, Norwegian Institute of Public Health, Oslo, Norway. ola.brynildsrud@fhi.no.
Abstract:
Genome-wide association studies (GWAS) have become indispensable in human medicine and genomics, but very few have been carried out on bacteria. Here we introduce Scoary, an ultra-fast, easy-to-use, and widely applicable software tool that scores the components of the pan-genome for associations to observed phenotypic traits while accounting for population stratification, with minimal assumptions about evolutionary processes. We call our approach pan-GWAS to distinguish it from traditional, single nucleotide polymorphism (SNP)-based GWAS. Scoary is implemented in Python and is available under an open source GPLv3 license at https://github.com/AdmiralenOla/Scoary .
Related Concept Videos
Genome-wide Association Studies-GWAS
GWAS does not require the identification of the target gene involved in...
DNA Microarrays
Genomics
Modern Molecular Taxonomy
Genomic DNA in Prokaryotes
Genomic Diversity in Bacteria
Although bacterial genomes are much...
RACE - Rapid Amplification of cDNA Ends

