Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Osteoclasts in Bone Remodeling01:31

Osteoclasts in Bone Remodeling

4.5K
Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during...
4.5K
Hormones and Bone Tissue01:17

Hormones and Bone Tissue

4.1K
The endocrine system produces and secretes hormones, which interact with the skeletal system. These hormones control bone growth, maintain bone once it is formed, and remodel it.
Hormones That Influence Osteoblasts and/or Maintain the Matrix
Several hormones are necessary for controlling bone growth and maintaining the bone matrix. The pituitary gland secretes growth hormone (GH), which, as its name implies, controls bone growth. This happens in several ways: first, it triggers chondrocyte...
4.1K
Bone Cells and Tissue01:30

Bone Cells and Tissue

9.2K
Bones contain a relatively small number of cells entrenched in a matrix of organic and inorganic components. Although bone cells compose only a small amount of the bone volume, they are crucial to its function. Four types of cells are found within the bone tissue— osteoblasts, osteocytes, osteogenic cells, and osteoclasts.
Osteoblasts and Osteocytes
The osteoblast is the bone cell responsible for forming new bone tissue. It is found in the growing portions of bone, including the...
9.2K
Bone Remodeling01:40

Bone Remodeling

40.8K
Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.
40.8K
The Functions of the Skeletal System01:22

The Functions of the Skeletal System

6.6K
The most apparent functions of the skeletal system are support, protection, and movement. However, bone tissue also performs several other critical metabolic functions. For one, the bone matrix acts as a reservoir for a number of minerals important to the functioning of the body, especially calcium and phosphorus. These minerals, present in the bone tissue, can be released back into the bloodstream when required. Calcium ions, for example, are essential for muscle contractions and controlling...
6.6K
What is the Skeletal System?01:02

What is the Skeletal System?

58.4K
Overview
58.4K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Programmed cell death ligand 1 (PD-L1) inhibition in tumor naïve mice is bone-sparing throughout the lifespan.

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research·2026
Same author

Global but not myeloid lineage-directed Girk3 deletion increases bone mass in female mice.

JBMR plus·2025
Same author

Programmed cell death protein 1 (PD-1) blockade regulates skeletal remodeling in a sex- and age-dependent manner.

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research·2025
Same author

Senescence profiling of monoclonal gammopathies reveals paracrine senescence as a crucial defense against disease progression.

Leukemia·2025
Same author

Efferocytosis and Bone Dynamics.

Current osteoporosis reports·2024
Same author

Modest Effects of Osteoclast-Specific ERα Deletion after Skeletal Maturity.

JBMR plus·2023

Related Experiment Video

Updated: Mar 11, 2026

Application of Retinoic Acid to Obtain Osteocytes Cultures from Primary Mouse Osteoblasts
07:13

Application of Retinoic Acid to Obtain Osteocytes Cultures from Primary Mouse Osteoblasts

Published on: May 13, 2014

14.0K

Sclerostin expression and functions beyond the osteocyte.

Megan M Weivoda1, Stephanie J Youssef1, Merry Jo Oursler1

  • 1Division of Endocrinology, Metabolism, Nutrition & Diabetes, Mayo Clinic, USA.

Bone
|November 27, 2016
PubMed
Summary

Sclerostin, an inhibitor of Wnt signaling, is produced by bone cells but also found elsewhere. Understanding its varied roles is crucial as new osteoporosis treatments targeting sclerostin emerge.

Keywords:
Ankylosing spondylitisOsteoarthritisRheumatoid arthritisSclerostinWnt

More Related Videos

IDG-SW3 Cell Culture in a Three-Dimensional Extracellular Matrix
10:48

IDG-SW3 Cell Culture in a Three-Dimensional Extracellular Matrix

Published on: November 13, 2023

1.7K
Skeletal Phenotype Analysis of a Conditional Stat3 Deletion Mouse Model
08:42

Skeletal Phenotype Analysis of a Conditional Stat3 Deletion Mouse Model

Published on: July 3, 2020

5.2K

Related Experiment Videos

Last Updated: Mar 11, 2026

Application of Retinoic Acid to Obtain Osteocytes Cultures from Primary Mouse Osteoblasts
07:13

Application of Retinoic Acid to Obtain Osteocytes Cultures from Primary Mouse Osteoblasts

Published on: May 13, 2014

14.0K
IDG-SW3 Cell Culture in a Three-Dimensional Extracellular Matrix
10:48

IDG-SW3 Cell Culture in a Three-Dimensional Extracellular Matrix

Published on: November 13, 2023

1.7K
Skeletal Phenotype Analysis of a Conditional Stat3 Deletion Mouse Model
08:42

Skeletal Phenotype Analysis of a Conditional Stat3 Deletion Mouse Model

Published on: July 3, 2020

5.2K

Area of Science:

  • Bone biology
  • Endocrinology
  • Cell signaling

Background:

  • Sclerostin, encoded by the SOST gene, inhibits Wnt signaling and regulates bone formation.
  • Osteocytes are primary producers, but SOST expression occurs in hypertrophic chondrocytes and cementocytes.
  • Altered SOST/sclerostin expression is noted in osteoarthritis and rheumatic joint disease.

Purpose of the Study:

  • To investigate the functions of sclerostin beyond its established role in bone formation.
  • To clarify sclerostin's role in pathological conditions like osteoarthritis and rheumatic joint disease.
  • To inform the development of anti-sclerostin therapies for osteoporosis.

Main Methods:

  • Literature review and analysis of existing studies on SOST/sclerostin expression and function.
  • Examination of sclerostin's presence in non-osteocyte cell types.
  • Review of evidence linking sclerostin to joint diseases.

Main Results:

  • Sclerostin is not exclusively produced by osteocytes, with expression found in chondrocytes and cementocytes.
  • The precise role of sclerostin in osteoarthritis and rheumatic joint disease pathogenesis remains unclear.
  • Evidence suggests sclerostin may have diverse functions influencing disease processes.

Conclusions:

  • A comprehensive understanding of sclerostin's functions beyond bone formation is essential.
  • Further research is needed to elucidate sclerostin's role in joint diseases.
  • This knowledge is critical for the safe and effective development of anti-sclerostin therapeutics.