Related Experiment Video

Updated: Mar 11, 2026

A Quantitative Measurement of Reactive Oxygen Species and Senescence-associated Secretory Phenotype in Normal Human Fibroblasts During Oncogene-induced Senescence
13:59

A Quantitative Measurement of Reactive Oxygen Species and Senescence-associated Secretory Phenotype in Normal Human Fibroblasts During Oncogene-induced Senescence

Published on: August 12, 2018

8.7K

Redox control of senescence and age-related disease

Akshaya Chandrasekaran1, Maria Del Pilar Sosa Idelchik1, J Andrés Melendez1

  • 1SUNY Polytechnic Institute, Colleges of Nanoscale Science and Engineering, 257 Fuller Road, Albany, NY 12203, USA.

Redox Biology
|November 28, 2016
PubMed

Insights

Reactive oxygen species (ROS) link cellular senescence and aging pathologies. Manipulating the redox environment offers therapeutic strategies to combat age-related diseases by controlling the senescence-associated secretory phenotype (SASP).

Area of Science:

  • Gerontology
  • Cellular Biology
  • Biochemistry

Background:

  • Aging is a complex process involving functional decline and disease.
  • Reactive oxygen species (ROS) are implicated in aging and age-related pathologies.
  • Cellular senescence, a tumor-suppressive mechanism, contributes to aging via the senescence-associated secretory phenotype (SASP).

Purpose of the Study:

  • To review biological theories of aging.
  • To elucidate the mechanistic role of ROS in senescence and aging.
  • To explore redox-regulated signaling networks controlling SASP and its role in age-related diseases.
  • To discuss therapeutic strategies targeting the cellular redox environment.

Main Methods:

  • Literature review of aging theories.
  • Analysis of ROS-mediated mechanisms in cellular senescence.
  • Examination of redox signaling pathways governing SASP.
  • Discussion of therapeutic interventions.

Main Results:

  • ROS act as a crucial signaling molecule connecting cellular senescence to age-associated pathologies.
  • The SASP, regulated by redox signaling, promotes pathogenic pathways contributing to aging.
  • Therapeutic manipulation of the cellular redox environment shows promise for restricting age-associated pathology.

Conclusions:

  • Understanding ROS and redox signaling is key to deciphering aging mechanisms.
  • Targeting cellular senescence and SASP through redox modulation offers a promising therapeutic avenue for age-related diseases.
Keywords:
AgingOxidative stressReactive oxygen species (ROS)SenescenceSenescence-associated secretory phenotype (SASP)

More Related Videos

Defining Hsp33's Redox-regulated Chaperone Activity and Mapping Conformational Changes on Hsp33 Using Hydrogen-deuterium Exchange Mass Spectrometry10:24

Defining Hsp33's Redox-regulated Chaperone Activity and Mapping Conformational Changes on Hsp33 Using Hydrogen-deuterium Exchange Mass Spectrometry

Published on: June 7, 2018

9.3K
Ratiometric Biosensors that Measure Mitochondrial Redox State and ATP in Living Yeast Cells12:22

Ratiometric Biosensors that Measure Mitochondrial Redox State and ATP in Living Yeast Cells

Published on: July 22, 2013

21.7K

Related Concept Videos

Redox Reactions01:27

Redox Reactions

Redox reactions are vital biochemical processes that underpin energy metabolism in cells. These reactions involve the transfer of electrons between molecules, occurring in tandem as oxidation and reduction. Oxidation refers to the loss of electrons, while reduction denotes their gain. This coupling ensures the seamless flow of electrons through metabolic pathways. For example, in bacterial metabolism, glucose undergoes oxidation to carbon dioxide, while oxygen is simultaneously reduced to...
1.3K
Redox Reactions01:24

Redox Reactions

Oxidation-reduction or redox reactions involve the transfer of electrons from one molecule or atom to another. When an atom gains an electron, another atom must lose an electron, meaning oxidation and reduction must occur together. Since the redox occurs in pairs, the atom that gets oxidized is also called the reducing agent or reductant, and the atom that is reduced is also called the oxidizing agent or oxidant. A straightforward way to remember the definitions of oxidation and reduction is...
59.2K
Electron Transport Chain: Complex I and II01:46

Electron Transport Chain: Complex I and II

The mitochondrial electron transport chain (ETC) is the main energy generation system in the eukaryotic cells. However, mitochondria also produce cytotoxic reactive oxygen species (ROS) due to the large electron flow during oxidative phosphorylation. While Complex I is one of the primary sources of superoxide radicals, ROS production by Complex II is uncommon and may only be observed in cancer cells with mutated complexes.
ROS generation is regulated and maintained at moderate levels necessary...
19.3K
Mitochondria01:37

Mitochondria

Mitochondria are eukaryotic cellular organelles that are known to produce energy through a process called oxidative phosphorylation. Besides their primary function, mitochondria are involved in various cellular processes, including cell growth, differentiation, signaling, metabolism, and senescence. Age-related changes cause a decline in mitochondrial quality and integrity due to increased mitochondrial mutations and oxidative damage. Thus, aging can severely impact mitochondrial functions,...
21.1K
Aging01:26

Aging

Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
938
Replicative Cell Senescence02:15

Replicative Cell Senescence

Replicative cell senescence is a property of cells that allows them to divide a finite number of times throughout the organism's lifespan while preventing excessive proliferation. Replicative senescence is associated with the gradual loss of the telomere — short, repetitive DNA sequences found at the end of the chromosomes. Telomeres are bound by a group of proteins to form a protective cap on the ends of chromosomes. Embryonic stem cells express telomerase — an enzyme that adds...
4.5K