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Immune-Related Adverse Effects of Cancer Immunotherapy- Implications for Rheumatology

Laura C Cappelli1, Ami A Shah1, Clifton O Bingham1

  • 1Division of Rheumatology, Johns Hopkins School of Medicine, 5501 Hopkins Bayview Circle, Suite 1.B1, Baltimore, MD, USA.

Rheumatic Diseases Clinics of North America
|November 29, 2016
PubMed

Immune checkpoint inhibitors (ICIs) are increasingly studied and used as therapy for a growing number of malignancies. ICIs work by blocking inhibitory pathways of T-cell activation, leading to an immune response directed against tumors. Such nonspecific immunologic activation can lead to immune-related adverse events (IRAEs). Some IRAEs, including inflammatory arthritis, sicca syndrome, myositis, and vasculitis, are of special interest to rheumatologists. As use of ICIs increases, recognition of these IRAEs and developing treatment strategies will become important. In this review, the current literature on rheumatic and musculoskeletal IRAEs is summarized. The incidence, clinical presentations, and treatment considerations are highlighted.

Keywords:
ArthritisImmune checkpoint inhibitorsImmune-related adverse eventsMalignancySicca syndrome

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