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Updated: Mar 11, 2026

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A Model for Perineural Invasion in Head and Neck Squamous Cell Carcinoma
Published on: January 5, 2017
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Imaging of Perineural Spread in Head and Neck Cancer
1Division of Neuroradiology, Johns Hopkins University, School of Medicine, 600 North Wolfe Street Phipps B100, Baltimore, MD 21287, USA.
Radiologic Clinics of North America
|November 29, 2016
Abstract:
Perineural spread (PNS) of tumor is a recognized pattern of metastasis occurring in the head and neck. Imaging plays a critical role in identifying PNS for adequate staging and treatment planning. Understanding the major branches and pathways of cranial nerves V and VII, key anatomic landmarks, interconnections between these nerves, and pearls and pitfalls of PNS imaging can aid in early detection, appropriate therapy, and the best possible chance for cure.

