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Mosaic Zebrafish Transgenesis for Functional Genomic Analysis of Candidate Cooperative Genes in Tumor Pathogenesis
Published on: March 31, 2015
Fish Oncology: Diseases, Diagnostics, and Therapeutics
Claire Vergneau-Grosset1, Marie-Eve Nadeau2, Joseph M Groff3
1Centre Hospitalier Vétérinaire Universitaire, Faculté de médecine vétérinaire, Université de Montréal, 3200 rue Sicotte, Saint-Hyacinthe J2S 2M2, Quebec, Canada; Aquarium du Québec, 1675 Avenue des Hôtels, Ville de Québec, QC G1W 4S3, Canada.
Abstract:
The scientific literature contains a wealth of information concerning spontaneous fish neoplasms, although ornamental fish oncology is still in its infancy. The occurrence of fish neoplasms has often been associated with oncogenic viruses and environmental insults, making them useful markers for environmental contaminants. The use of fish, including zebrafish, as models of human carcinogenesis has been developed and knowledge gained from these models may also be applied to ornamental fish, although more studies are required. This review summarizes information available about fish oncology pertaining to veterinary clinicians.
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