Related Experiment Video
Updated: Mar 11, 2026
08:08
Increasing Pulmonary Artery Pulsatile Flow Improves Hypoxic Pulmonary Hypertension in Piglets
Published on: May 11, 2015
14.7K
Noninvasive Positive Pressure Ventilation in Chronic Heart Failure
Hao Jiang1, Yi Han2, Chenqi Xu3
1Department of Cardiovascular Diseases, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Canadian Respiratory Journal
|November 29, 2016
Summary
Noninvasive positive pressure ventilation (NPPV) improved cardiac function, specifically left ventricular ejection fraction (LVEF) and reduced brain natriuretic peptide (BNP) levels in chronic heart failure patients. However, NPPV did not significantly impact overall mortality in this population.
Area of Science:
- Cardiology
- Pulmonology
- Medical Technology
Background:
- Sleep-disordered breathing (SDB) is linked to cardiac dysfunction.
- Noninvasive positive pressure ventilation (NPPV) is a potential treatment for SDB and may improve cardiac function.
- Large-scale trials on NPPV's cardiac effects in heart failure are limited.
Purpose of the Study:
- To evaluate the effectiveness of NPPV in improving cardiac function in patients with chronic heart failure.
- To analyze the impact of NPPV on left ventricular ejection fraction (LVEF) and plasma brain natriuretic peptide (BNP) levels.
- To assess the effect of NPPV on overall mortality in this patient group.
Main Methods:
- A meta-analysis of published controlled trials was conducted.
- Studies were identified through searches in PubMed, OVID, and EMBASE databases.
- Primary outcomes included LVEF, BNP levels, and overall mortality, analyzed using fixed and random models.
Main Results:
- Nineteen studies with 843 patients were included in the analysis.
- NPPV combined with standard medical treatment (SMT) significantly improved LVEF (WMD 5.34, P < 0.00001) compared to SMT alone or with sham-NPPV.
- NPPV also led to a significant reduction in plasma BNP levels (WMD -117.37, P = 0.04) but showed no effect on overall mortality (RR 1.00, P = 0.95).
Conclusions:
- NPPV, when used with SMT, is effective in improving cardiac function in patients with chronic heart failure.
- The treatment enhances LVEF and reduces BNP levels, indicating a positive impact on cardiac health.
- NPPV does not appear to influence overall mortality in patients with chronic heart failure based on current evidence.
More Related Videos
Related Concept Videos
01:23Mechanical Ventilation III: Noninvasive Ventilation
715
Noninvasive positive-pressure ventilation (NIPPV), continuous positive airway pressure (CPAP), and bilevel positive airway pressure (BiPAP) are essential methods in respiratory care. These ventilation techniques offer unique benefits for patients with various respiratory conditions, providing adequate support without requiring intubation. Let's explore how each method is crucial in improving patient outcomes and enhancing respiratory therapy.
Noninvasive Positive-Pressure Ventilation...
Noninvasive Positive-Pressure Ventilation...
715
01:23Mechanical Ventilation II: Invasive Ventilation
918
Ventilators are essential medical equipment used to aid patients with respiratory difficulties. Their primary function is to assist or replace spontaneous breathing by providing mechanical ventilation. There are two general classes of mechanical ventilators: negative-pressure and positive-pressure ventilators.
Negative-Pressure Ventilators
Negative-pressure ventilators create a vacuum around the chest or body to draw air into the lungs, simulating breathing. This method does not require an...
Negative-Pressure Ventilators
Negative-pressure ventilators create a vacuum around the chest or body to draw air into the lungs, simulating breathing. This method does not require an...
918
01:29Mechanical Ventilation I: Indication and Settings
3.4K
Mechanical ventilation is a life-saving technique for managing acute respiratory failure and other respiratory complications. The process involves using a machine known as a ventilator to supply oxygen to the lungs and assist in removing carbon dioxide. It serves as a bridge to long-term mechanical ventilation or a temporary measure until ventilatory support is discontinued. The ventilator can maintain this function for a prolonged period, providing critical support for patients until they can...
3.4K
01:14Ventilatory Modes
1.9K
Mechanical ventilators are life-saving devices that support or replace spontaneous breathing. They deliver breaths to patients through varying methods known as ventilator modes. Understanding these modes is critical for healthcare providers managing patients with respiratory failure.
There are three ventilatory modes: full support, partial support, and spontaneous. These are described below.
Full Support Modes
Full support modes include controlled mechanical ventilation, continuous mandatory...
There are three ventilatory modes: full support, partial support, and spontaneous. These are described below.
Full Support Modes
Full support modes include controlled mechanical ventilation, continuous mandatory...
1.9K
01:30Heart Failure V: Medical Management
455
Medical Management of Acute Decompensated Heart Failure (ADHF)The primary goals of therapy for patients hospitalized with acute decompensated heart failure (ADHF) include:Relieving symptomsOptimizing volume statusSupporting oxygenation and ventilationMaintaining cardiac output (CO) and end-organ perfusionIdentifying and addressing the cause of ADHFPreventing complicationsProviding patient education on factors precipitating HF exacerbationPlanning for dischargeOngoing monitoring and assessment...
455
01:27Chronic Obstructive Pulmonary Disease-IV: Assessement and Diagnostic Studies
3.3K
Assessing and diagnosing Chronic Obstructive Pulmonary Disease (COPD) involves a detailed approach that includes a comprehensive review of medical history, physical examination, and a variety of diagnostic tests. This thorough evaluation is essential to ensure an accurate diagnosis and guide effective management strategies.
Medical History
Medical History
3.3K