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Updated: Mar 11, 2026

Author Spotlight: Advances in Brain Energy Metabolism Research Using the Drosophila Model
Published on: October 27, 2023
Effect of different glucose supply conditions on neuronal energy metabolism
Hongwen Zheng1, Rubin Wang1, Jingyi Qu1
1The Institute for Cognitive Neurodynamics, East China University of Science and Technology, No. 130 Meilong Road, Xuhui District, 200237 Shanghai China.
Abstract:
The glucose-excited neurons in brain can sense blood glucose levels and reflect different firing states, which are mainly associated with regulation of blood glucose and energy demand in the brain. In this paper, a new model of glucose-excited neuron in hypothalamus is proposed. The firing properties and energy consumption of this type of neuron under conditions of different glucose levels are simulated and analyzed. The results show that the firing rate and firing duration of the neuron both increase with increasing extracellular glucose levels, but the maximum energy power for an AP is reduced. Further study suggests that the neuron firstly absorbs energy substrates (e.g. glucose) from the blood to prepare for the high energy demand of high-frequency spikes.
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