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Updated: Mar 11, 2026

Real-time Monitoring of Ligand-receptor Interactions with Fluorescence Resonance Energy Transfer
Published on: August 20, 2012
Ionic complex of a rhodamine dye with aggregation-induced emission properties
Pei-Yi Huang1, Jhen-Yan Gao1, Cheng-Yu Song1
1Department of Materials and Optoelectronic Science, National Sun Yat-sen University, Kaohsiung 80424, Taiwan, Republic of China. jlhong@mail.nsysu.edu.tw.
Abstract:
An AIE-active rhodamine based luminogen was prepared via a complexation reaction between non-emissive rhodamine hydrazide (RdH) and bulky camphorsulfonic acid (CSA). Besides acting to open the spirolactam ring of RdH, CSA also imposes a rotational restriction on the resultant ionic complex, RdH(CSA)x. Without CSA, the analogous complex RdH(HCl)3 is a luminogen with aggregation-caused quenching (ACQ) properties. The ionic bonds of RdH(CSA)3 are sensitive to several external stimuli and therefore it is a luminescent sensor for metal ions, organic amines and the blood protein bovine serum albumin (BSA). Besides being a sensor for BSA, the ionic RdH(CSA)3 is also a denaturant capable of uncoiling the peptide chain of BSA.
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