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Postoperative zygomycetes endophthalmitis.

I K Orgel1, K L Cohen

  • 1Department of Ophthalmology, University of North Carolina, School of Medicine, Chapel Hill.

Ophthalmic Surgery
|August 1, 1989
PubMed
Summary

This study details the first reported case of Zygomycetes endophthalmitis after cataract surgery. Prompt treatment with intraocular amphotericin B was successful, potentially due to the intact posterior capsule.

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Area of Science:

  • Ophthalmology
  • Mycology
  • Infectious Diseases

Background:

  • Fungal endophthalmitis is a rare but serious complication following intraocular surgery.
  • Zygomycetes infections are particularly aggressive and uncommon in this context.

Observation:

  • A case of Zygomycetes endophthalmitis occurred post-phacoemulsification with intraocular lens implantation.
  • Initial aqueous and vitreous cultures were negative for fungal pathogens.

Findings:

  • Diagnosis was confirmed via immunofluorescence staining of an anterior chamber inflammatory mass.
  • Successful treatment was achieved using 20 micrograms of intraocular amphotericin B.
  • An intact posterior capsule may have localized the infection, aiding treatment efficacy.

Implications:

  • Highlights the importance of considering rare fungal pathogens in postoperative endophthalmitis, even with negative cultures.
  • Suggests intraocular amphotericin B as a viable treatment option for Zygomycetes endophthalmitis.
  • Emphasizes the potential role of ocular compartmentalization in managing severe intraocular infections.

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