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MARK inhibitors: Declaring a No-Go decision on a chemical series based on extensive DMPK experimentation

Andrew M Haidle1, Kaleen K Childers1, Anna A Zabierek1

  • 1Department of Chemistry, Merck & Co., Inc., 33 Avenue Louis Pasteur, Boston, MA 02115, USA.

Bioorganic & Medicinal Chemistry Letters
|November 30, 2016
PubMed

Keywords:
Disposition studyIn vitro–in vivo correlationKinaseMARKOptimizationPharmacokineticsPhysical properties

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