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Updated: Mar 11, 2026

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Published on: September 30, 2021
Hepatitis C infection and renal cell carcinoma: A systematic review and meta-analysis
Karn Wijarnpreecha1, Pitchaphon Nissaisorakarn1, Suthanya Sornprom1
1Karn Wijarnpreecha, Suthanya Sornprom, Charat Thongprayoon, Natanong Thamcharoen, Department of Internal Medicine, Bassett Medical Center, Cooperstown, NY 13326, United States.
Aim:
To investigate the association between hepatitis C virus (HCV) infection and risk of renal cell carcinoma (RCC).
Methods:
A literature search was performed from inception until February 2016. Studies that reported relative risks, odd ratios, hazard ratios or standardized incidence ratio comparing the risk of RCC among HCV-infected participants vs those without HCV infection were included. Participants without HCV infection were used as comparators. Pooled odds ratios and 95%CI were calculated using a random-effect, generic inverse variance method.
Results:
Seven observational studies were with 196826 patients were included in the analysis to assess the risk of RCC in patients with HCV. A significantly increased risk of RCC among participants with HCV infection was found with a pooled RR of 1.86 (95%CI: 1.11-3.11). The association between RCC and HCV was marginally insignificant after a sensitivity analysis limited only to studies with adjusted analysis, with a pooled RR of 1.50 (95%CI: 0.93-2.42).
Conclusion:
Our study demonstrated a potential association between HCV infection and RCC. Further studies of RCC surveillance in patients with HCV are required.
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