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Plasma-Lyte 148: A clinical review.

Laurence Weinberg1, Neil Collins1, Kiara Van Mourik1

  • 1Laurence Weinberg, Department of Surgery, Perioperative Pain Medicine Unit, University of Melbourne, Victoria 3084, Australia.

World Journal of Critical Care Medicine
|November 30, 2016
PubMed
Summary

Plasma-Lyte 148, a buffered crystalloid solution, closely mimics human plasma. Emerging evidence suggests its use over saline in fluid therapy for improved outcomes, though more trials are needed.

Keywords:
AcetateAnesthesiaCrystalloidsFluid therapyGluconateHartmann’sLactatePlasma-LyteRingersSalineSurgery

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Area of Science:

  • Intravenous fluid therapy
  • Critical care medicine
  • Perioperative management

Background:

  • Plasma-Lyte 148 is an isotonic, buffered crystalloid solution.
  • Its physiochemical properties closely resemble human plasma.
  • Fluid intervention is crucial in critical illness, surgery, and perioperative care.

Purpose of the Study:

  • To review the physiochemical properties of Plasma-Lyte 148.
  • To outline its clinical applications in fluid management.
  • To compare Plasma-Lyte 148 with other crystalloid solutions.

Main Methods:

  • Electronic literature search of Medline, PubMed, textbooks, and online sources.
  • Keywords included various fluid therapy and crystalloid terms.
  • Data from 104 relevant articles were summarized.

Main Results:

  • Plasma-Lyte 148 exhibits physiochemical properties similar to human plasma.
  • Emerging data supports buffered crystalloids over saline for better outcomes.
  • Analysis of 104 articles informed the findings.

Conclusions:

  • Plasma-Lyte 148 is a viable option for fluid intervention.
  • Buffered crystalloids may offer advantages over saline.
  • Further large randomized trials are necessary to confirm clinical benefits.