Maternal Fructose Intake Affects Transcriptome Changes and Programmed Hypertension in Offspring in Later Life

Area of Science:

• Developmental origins of health and disease (DOHaD)
• Nutrient-gene interactions
• Renal programming

Background:

• Hypertension is linked to early-life factors.
• Maternal high-fructose (HF) consumption is associated with increased hypertension risk in offspring.
• Understanding nutrient-gene interactions is crucial for preventing programmed hypertension.

Purpose of the Study:

• To review the impact of maternal HF consumption on offspring's renal transcriptome and programmed hypertension.
• To explore metabolic effects of fructose on hypertension and kidney disease.
• To examine the efficacy of reprogramming interventions against HF-induced programmed hypertension.

Main Methods:

• Literature review focusing on maternal HF intake effects.
• Analysis of studies on renal transcriptome changes.
• Examination of animal models for reprogramming interventions.

Main Results:

• Maternal HF intake alters renal transcriptome, contributing to programmed hypertension.
• Reprogramming interventions show protective effects against hypertension.
• Fructose metabolism significantly impacts hypertension and kidney disease development.

Conclusions:

• Maternal HF consumption poses risks for offspring hypertension through renal programming.
• Early-life nutrient-gene interactions are key targets for intervention.
• Developing effective reprogramming strategies is essential for preventing and treating hypertension.