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Robust Ligature-Induced Model of Murine Periodontitis for the Evaluation of Oral Neutrophils
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Viruses: Bystanders of periodontal disease

Titiksha Aggarwal1, Arundeep Kaur Lamba1, Farrukh Faraz1

  • 1Department of Periodontics at Maulana Azad Institute of Dental Sciences, Bahadurshah Zafar Marg, New Delhi 110002, India.

Microbial Pathogenesis
|December 1, 2016
PubMed

Insights

While bacteria cause periodontal disease, viruses may also play a role. This review explores viral mechanisms in periodontal disease development, suggesting broader etiological concepts for improved treatment.

Area of Science:

  • Periodontology
  • Microbiology
  • Infectious Diseases

Background:

  • Bacterial infection is the established cause of periodontal disease.
  • Despite antibiotic advancements, periodontal disease prevalence remains high.
  • Disease patterns and unpredictable remissions necessitate exploring alternative etiologies.

Purpose of the Study:

  • To review the role of viruses in periodontal disease development.
  • To elucidate plausible mechanisms of viral impact on periodontal tissues.
  • To broaden the understanding of periodontal disease etiology.

Main Methods:

  • Literature review of existing studies on viruses and periodontal disease.
  • Analysis of proposed mechanisms for viral involvement.
  • Synthesis of current knowledge on viral-bacterial interactions in periodontal disease.

Main Results:

  • Viruses are increasingly recognized as potential contributors to periodontal disease.
  • Specific viral mechanisms may exacerbate inflammation and tissue destruction.
  • Viral co-infections could influence disease progression and treatment outcomes.

Conclusions:

  • Viral etiology is a plausible factor in periodontal disease, complementing bacterial roles.
  • Understanding viral contributions can lead to more comprehensive diagnostic and therapeutic strategies.
  • Further research into viral pathogenesis is crucial for advancing periodontal care.

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