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Related Experiment Videos

Yohimbine increases human salivary secretion.

E Chatelut1, Y Rispail, M Berlan

  • 1Laboratoire de Pharmacologie Médicale et Clinique, INSERM U317, Faculté de Médecine, Toulouse, France.

British Journal of Clinical Pharmacology
|September 1, 1989
PubMed
Summary

Oral yohimbine significantly boosted saliva production in healthy individuals compared to a placebo. This finding suggests yohimbine may help treat dry mouth conditions.

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Area of Science:

  • Pharmacology
  • Physiology
  • Salivary Gland Biology

Background:

  • Xerostomia (dry mouth) affects numerous individuals, impacting oral health and quality of life.
  • Current treatments for dry mouth have limitations, necessitating exploration of novel therapeutic agents.

Purpose of the Study:

  • To investigate the effect of oral yohimbine on salivary secretion in healthy volunteers.
  • To determine the time course and significance of yohimbine-induced salivation.

Main Methods:

  • A randomized, placebo-controlled study was conducted with healthy volunteers.
  • Participants received a single oral dose of 14 mg yohimbine or a placebo.
  • Salivary secretion rates were measured at various time points post-administration.

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Main Results:

  • Yohimbine administration resulted in a statistically significant increase in salivary secretion compared to placebo.
  • The enhanced salivary secretion was observed from 60 minutes up to 180 minutes after yohimbine intake.
  • No adverse effects were reported during the study period.

Conclusions:

  • Oral yohimbine effectively stimulates salivary secretion in healthy individuals.
  • Yohimbine, as an alpha 2-adrenoceptor antagonist, shows potential as a therapeutic agent for managing dry mouth.
  • Further clinical trials are warranted to confirm the efficacy and safety of yohimbine for treating xerostomia.