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Related Experiment Video

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Laser Capture Microdissection of Neurons from Differentiated Human Neuroprogenitor Cells in Culture
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New insight into LSD1 function in human cortical neurogenesis.

Kazumi Hirano1, Masakazu Namihira1

  • 1Molecular Neurophysiology Research Group, Biomedical Research Institute, The National Institute of Advanced Industrial Science and Technology (AIST) , Japan.

Neurogenesis (Austin, Tex.)
|December 1, 2016
PubMed
Summary

Lysine-specific demethylase 1 (LSD1) uniquely regulates human neural stem cells (NSCs) for neuronal differentiation by controlling HEYL expression, a key factor in human brain evolution.

Keywords:
HEYLLSD1cerebral cortexepigeneticshistone methylationneural stem cellneurogenesisnotch

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Area of Science:

  • Neuroscience
  • Developmental Biology
  • Epigenetics

Background:

  • Primate cerebral cortex evolution is linked to neural stem cell (NSC) changes.
  • Epigenetic factors regulate rodent corticogenesis, but their role in humans is unclear.

Purpose of the Study:

  • Investigate the role of lysine-specific demethylase 1 (LSD1) in human fetal neural stem cells (hfNSCs).
  • Determine LSD1's function in human corticogenesis and its relation to HEYL expression.

Main Methods:

  • Studied LSD1 function in hfNSCs.
  • Analyzed histone modification on the HEYL promoter.
  • Assessed HEYL's role in maintaining hfNSC state.

Main Results:

  • LSD1 is essential for neuronal differentiation in hfNSCs, unlike in mice.
  • LSD1 modulates histone methylation on the HEYL promoter, controlling its expression.
  • HEYL maintains the undifferentiated state of hfNSCs.

Conclusions:

  • LSD1 plays a distinct, crucial role in human corticogenesis.
  • LSD1-mediated HEYL regulation may contribute to the evolution of the primate cerebral cortex.